X 射线可引发 FLASH 效应：超强剂量率同步加速器光源可防止全脑照射后小鼠的正常脑损伤。
X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
机构信息
Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital, Switzerland.
Rayonnement synchrotron et Recherche médicale, Université Grenoble Alpes, 38000 Grenoble, France.
出版信息
Radiother Oncol. 2018 Dec;129(3):582-588. doi: 10.1016/j.radonc.2018.08.016. Epub 2018 Aug 31.
PMID:30177374
Abstract
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
摘要
这项研究首次证明了 X 射线可以引发 FLASH 效应。我们的结果表明，用同步加速器产生的 X 射线以超高剂量率进行 10Gy 的全脑照射不会引起记忆缺陷；它减少了海马神经元分裂损伤，并诱导较少的反应性星形胶质细胞增生。
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