瞬间照射：在剂量率高于 100Gy/s 的全脑照射后，小鼠的记忆得到独特的保护。
Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.
机构信息
Department of Radiation Oncology/DO/CHUV, Lausanne University Hospital, Switzerland; Institut Curie, INSERM U1021/CNRS UMR3347, Université Paris-Saclay, Orsay, France.
Institute of Radiation Physics (IRA), Lausanne University Hospital, Switzerland.
出版信息
Radiother Oncol. 2017 Sep;124(3):365-369. doi: 10.1016/j.radonc.2017.05.003. Epub 2017 May 22.
PMID:28545957
Abstract
This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.
摘要
本研究首次表明，提高剂量率可降低 WBI 后的正常脑组织毒性。在平均剂量率高于 100Gy/s 时，WBI 后空间记忆得以保留，而在传统放疗剂量率（0.1Gy/s）下进行 10Gy 的 WBI 则会完全损害空间记忆。
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