Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Postgrad Med J. 2018 Sep;94(1115):517-524. doi: 10.1136/postgradmedj-2018-135839. Epub 2018 Sep 3.
Soluble urokinase plasminogen activator receptor (suPAR) is a circulating form of a physiological and pathophysiological important cell surface receptor, implicated in inflammation. Recent studies showed that suPAR is a promising biomarker, useful for diagnosis, assessment and prognosis of several diseases. This review summarises the majority of preliminary studies and analyses the significance and the clinical application of suPAR in various clinical conditions. SuPAR seems to have a significant value in the diagnosis as well as prognosis of many diseases; nonetheless, it merits large-scale studies to set cut-off values that help physicians in following up their patients and accordingly tailor their treatment plans.
可溶性尿激酶型纤溶酶原激活物受体（suPAR）是一种循环形式的生理和病理生理学上重要的细胞表面受体，与炎症有关。最近的研究表明，suPAR 是一种很有前途的生物标志物，可用于多种疾病的诊断、评估和预后。本综述总结了大多数初步研究，并分析了 suPAR 在各种临床情况下的意义和临床应用。suPAR 在许多疾病的诊断和预后中似乎具有重要价值；然而，需要进行大规模的研究来确定有助于医生跟踪患者并相应地调整治疗计划的截断值。
