Department of Laboratory Diagnostics and Clinical Biochemistry, Medical University of Lodz, Lodz, Poland.
Department of Geriatrics, Medical University of Lodz, Lodz, Poland.
Sci Rep. 2020 Sep 22;10(1):15462. doi: 10.1038/s41598-020-72377-w.
Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker whose clinical value has been tested in various groups of patients. The aim of the present study was to determine the suPAR level in a previously uninvestigated population of 182, generally healthy, community-dwelling seniors aged 74-89 years. In addition to suPAR level, selected laboratory parameters of heart and kidney function, lipid and C-reactive protein levels were determined. A group of 45 younger individuals aged 24-66 years was used for comparison. The seniors had higher suPAR levels than younger controls: 3.79 ng/mL (95% CI 3.64-3.96 ng/mL) vs. 3.16 ng/mL (95% CI 2.86-3.45 ng/mL). These levels increased further with advancing age, and were similar in women and men. A multiple regression model confirmed that biomarker level was related to cardiac function, renal function and inflammation, and this remained after adjusting for age. These correlation patterns were similar in older women and men.
可溶性尿激酶型纤溶酶原激活物受体（suPAR）是一种生物标志物，其临床价值已在各种患者群体中得到验证。本研究的目的是确定 182 名年龄在 74-89 岁、一般健康、居住在社区的老年人中尚未研究过的人群的 suPAR 水平。除 suPAR 水平外，还测定了心脏和肾功能、血脂和 C 反应蛋白水平等选定的实验室参数。将年龄在 24-66 岁的 45 名年轻个体用作对照组。老年人的 suPAR 水平高于年轻对照组：3.79ng/mL（95%CI 3.64-3.96ng/mL）vs.3.16ng/mL（95%CI 2.86-3.45ng/mL）。这些水平随着年龄的增长进一步升高，且在女性和男性中相似。多元回归模型证实生物标志物水平与心脏功能、肾功能和炎症有关，即使在调整年龄后，这种相关性仍然存在。在老年女性和男性中，这些相关性模式相似。
