Yoshino Atsuo, Aizawa Hidenori, Takamura Masahiro, Ichikawa Naho, Shibasaki Chiyo, Yamawaki Yosuke, Sasaoka Takafumi, Okamoto Yasumasa, Yamawaki Shigeto
Department of Psychiatry and Neurosciences, Hiroshima University.
Brain Nerve. 2018 Sep;70(9):1017-1023. doi: 10.11477/mf.1416201121.
Depression has various symptoms, such as depressed mood or loss of motivation, and the pathophysiological mechanisms remain unclear. Recent studies have increased the understanding of the role of the habenula, since the habenula is reported to control the metabolism of monoamine neurotransmitters in the brain through direct projections to the ventral tegmental area and raphe nucleus. Human neuroimaging studies have been performed to attempt to clarify the mechanisms of depression. This manuscript mainly introduces human neuroimaging studies of the role of the habenula in depression.
抑郁症有多种症状，如情绪低落或动力丧失，其病理生理机制尚不清楚。最近的研究增进了对缰核作用的理解，因为据报道缰核通过直接投射到腹侧被盖区和中缝核来控制大脑中单胺类神经递质的代谢。已经开展了人类神经影像学研究以试图阐明抑郁症的机制。本手稿主要介绍关于缰核在抑郁症中作用的人类神经影像学研究。
