Prakash Chander, Singh Sunpreet, Gupta Munish Kumar, Mia Mozammel, Królczyk Grzegorz, Khanna Navneet
School of Mechanical Engineering, Lovely Professional University, Phagwara, Punjab 144411, India.
Mechanical Engineering Department, National Institute of Technology, Hamirpur 177005, India.
Materials (Basel). 2018 Sep 3;11(9):1602. doi: 10.3390/ma11091602.
Recently, magnesium (Mg) has gained attention as a potential material for orthopedics devices, owing to the combination of its biodegradability and similar mechanical characteristics to those of bones. However, the rapid decay rate of Mg alloy is one of the critical barriers amongst its widespread applications that have provided numerous research scopes to the scientists. In this present, porous Mg-based biodegradable structures have been fabricated through the hybridization of elemental alloying and spark plasma sintering technology. As key alloying elements, the suitable proportions of silicon (Si) and hydroxyapatite (HA) are used to enhance the mechanical, chemical, and geometrical features. It has been found that the addition of HA and Si element results in higher degree of structural porosity with low elastic modulus and hardness of the Mg⁻Zn⁻Mn matrix, respectively. Further, addition of both HA and Si elements has refined the grain structure and improved the hardness of the as-fabricated structures. Moreover, the characterization results validate the formation of various biocompatible phases, which enhances the corrosion performance and biomechanical integrity. Moreover, the fabricated composites show an excellent bioactivity and offer a channel/interface to MG-63 cells for attachment, proliferation and differentiation. The overall results of the present study advocate the usefulness of developed structures for orthopedics applications.
最近，镁（Mg）因其生物可降解性以及与骨骼相似的机械特性，作为骨科器械的潜在材料受到了关注。然而，镁合金的快速腐蚀速率是其广泛应用的关键障碍之一，这为科学家们提供了众多研究方向。目前，通过元素合金化与放电等离子烧结技术相结合，制备出了多孔镁基可生物降解结构。作为关键合金元素，硅（Si）和羟基磷灰石（HA）的适当比例被用于增强机械、化学和几何特性。研究发现，添加HA和Si元素分别导致Mg⁻Zn⁻Mn基体具有更高程度的结构孔隙率、较低的弹性模量和硬度。此外，同时添加HA和Si元素细化了晶粒结构，提高了制备结构的硬度。而且，表征结果证实了各种生物相容性相的形成，这增强了腐蚀性能和生物力学完整性。此外，制备的复合材料表现出优异的生物活性，并为MG-63细胞提供了附着、增殖和分化的通道/界面。本研究的总体结果表明所开发的结构在骨科应用中具有实用性。
