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Commentary: Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!

作者信息

Pollet Marius, Krutmann Jean, Haarmann-Stemmann Thomas

机构信息

IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.

Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

出版信息

Front Pharmacol. 2018 Aug 20;9:935. doi: 10.3389/fphar.2018.00935. eCollection 2018.

DOI:10.3389/fphar.2018.00935
PMID:30177882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6110190/
Abstract
摘要

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本文引用的文献

1
Usage of Mitogen-Activated Protein Kinase Small Molecule Inhibitors: More Than Just Inhibition!丝裂原活化蛋白激酶小分子抑制剂的用途：不止于抑制！
Front Pharmacol. 2018 Feb 12;9:98. doi: 10.3389/fphar.2018.00098. eCollection 2018.
2
Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options.CYP1A1 代谢的调节：从不良健康影响到化学预防和治疗选择。
Pharmacol Ther. 2018 Jul;187:71-87. doi: 10.1016/j.pharmthera.2018.02.012. Epub 2018 Feb 17.
3
And Now for Something Completely Different: Diversity in Ligand-Dependent Activation of Ah Receptor Responses.现在来看一些完全不同的内容：芳烃受体反应的配体依赖性激活中的多样性。
Curr Opin Toxicol. 2017 Feb;2:124-131. doi: 10.1016/j.cotox.2017.01.006.
4
Non-kinase targets of protein kinase inhibitors.蛋白激酶抑制剂的非激酶靶点。
Nat Rev Drug Discov. 2017 Jun;16(6):424-440. doi: 10.1038/nrd.2016.266. Epub 2017 Mar 10.
5
FDA-approved small-molecule kinase inhibitors.美国食品和药物管理局批准的小分子激酶抑制剂。
Trends Pharmacol Sci. 2015 Jul;36(7):422-39. doi: 10.1016/j.tips.2015.04.005. Epub 2015 May 12.
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Aryl hydrocarbon receptor ligands in cancer: friend and foe.癌症中的芳烃受体配体：亦敌亦友
Nat Rev Cancer. 2014 Dec;14(12):801-14. doi: 10.1038/nrc3846.
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Arch Toxicol. 2015 Aug;89(8):1329-36. doi: 10.1007/s00204-014-1321-8. Epub 2014 Aug 1.
8
U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.U0126，一种丝裂原活化蛋白激酶激酶 1 和 2（MEK1 和 2）抑制剂，通过 HepG2 细胞中的孕烷 X 受体（PXR）选择性地上调 CYP3A 亚家族的主要同工酶。
Arch Toxicol. 2014 Dec;88(12):2243-59. doi: 10.1007/s00204-014-1254-2. Epub 2014 May 14.
9
Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation.舒尼替尼是一种酪氨酸激酶抑制剂，通过非配体依赖的芳香烃受体激活诱导人乳腺癌 MCF7 细胞细胞色素 P4501A1 基因。
Arch Toxicol. 2013 May;87(5):847-56. doi: 10.1007/s00204-012-0996-y. Epub 2013 Jan 4.
10
PXR-mediated P-glycoprotein induction by small molecule tyrosine kinase inhibitors.小分子酪氨酸激酶抑制剂介导的 PXR 诱导 P-糖蛋白表达。
Eur J Pharm Sci. 2013 Mar 12;48(4-5):644-9. doi: 10.1016/j.ejps.2012.12.019. Epub 2012 Dec 28.