Denison Michael S, Faber Samantha C
Department of Environmental Toxicology, University of California, Davis, CA, 95616, USA.
Curr Opin Toxicol. 2017 Feb;2:124-131. doi: 10.1016/j.cotox.2017.01.006.
Ligand-dependent activation of the Ah receptor (AhR) can result in an extremely diverse spectrum of biological and toxic effects that occur in a ligand-, species- and tissue-specific manner. While the classical mechanism of AhR-dependent signal transduction is directly related to its ability to modulate gene expression, the dramatic diversity in responses observed following AhR activation or inhibition is inconsistent with a single molecular mechanism of AhR action. Recent studies have revealed that key molecular events underlying the AhR signaling pathway are significantly more varied and complex than previously established, and the specificity and diversity in AhR response can be selectively modulated by a variety of factors. Here we describe new insights into the mechanistic diversity in AhR signal transduction that can contribute to ligand-, species- and tissue-specific differences in AhR reponse.
芳烃受体（AhR）的配体依赖性激活可导致极其多样的生物学和毒性效应，这些效应以配体、物种和组织特异性的方式出现。虽然AhR依赖性信号转导的经典机制与其调节基因表达的能力直接相关，但在AhR激活或抑制后观察到的反应的显著多样性与AhR作用的单一分子机制不一致。最近的研究表明，AhR信号通路的关键分子事件比以前所确定的要更加多样和复杂，并且AhR反应的特异性和多样性可被多种因素选择性地调节。在此，我们描述了对AhR信号转导机制多样性的新见解，这些见解有助于解释AhR反应中配体、物种和组织特异性的差异。
