Biomedical Optics Research Laboratory (BORL), Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Institute of Complementary Medicine, University of Bern, Bern, Switzerland.
Adv Exp Med Biol. 2018;1072:157-161. doi: 10.1007/978-3-319-91287-5_25.
In preterm neonates, the cardiovascular and cerebral vascular control is immature, making the brain vulnerable to an increased incidence of hypoxic and hyperoxic episodes.
The aim of the study was to apply the recently developed multiple Einstein's cross wavelet analysis (MECWA) to quantify the coupling of fluctuations of peripherally measured arterial oxygen saturation (SpO), cerebral tissue oxygen saturation (StO) and heart rate (HR).
Two long-term measurements on preterm neonates with a gestational age at birth of 26.4 and 26.8 weeks and a postnatal age of 2.1 and 3.9 weeks were analyzed. MECWA was applied to SpO, StO and HR.
MECWA showed that the fluctuations of SpO, StO and HR were synchronized in the low-frequency range with periods of ~1 h and ~0.5 h. The amplitudes of the synchronization frequencies were dependent on the individual neonate.
MECWA is a useful novel tool to assess the coupling of physiological signals. The parameters determined by MECWA seem to be related to the chronobiological processes, as well as constant regulations of the cardiovascular and cerebral perfusion state.
MECWA was able to identify long-term synchronization of the cardiovascular and cerebral perfusion state in preterm neonates with periods of ~1 h and ~0.5 h.
在早产儿中，心血管和脑血管控制不成熟，使大脑容易受到更多的缺氧和高氧发作的影响。
本研究旨在应用新开发的多爱因斯坦交叉小波分析（MECWA）来量化外周动脉血氧饱和度（SpO）、脑组织氧饱和度（StO）和心率（HR）波动的耦合。
对胎龄分别为 26.4 周和 26.8 周、出生后年龄分别为 2.1 周和 3.9 周的两名早产儿进行了两次长期测量。MECWA 应用于 SpO、StO 和 HR。
MECWA 显示 SpO、StO 和 HR 的波动在低频范围内同步，周期约为 1 小时和 0.5 小时。同步频率的幅度取决于个体早产儿。
MECWA 是一种评估生理信号耦合的有用新工具。MECWA 确定的参数似乎与生理节律过程以及心血管和脑灌注状态的恒定调节有关。
MECWA 能够识别早产儿的心血管和脑灌注状态在 1 小时和 0.5 小时左右的长期同步。
