Laboratory of Laser Sports Medicine, South China Normal University, Guangzhou, China.
School of Electronic Information, Nantong University, Nantong, China.
Adv Exp Med Biol. 2018;1072:281-285. doi: 10.1007/978-3-319-91287-5_45.
Luongo et al. found that the mitochondrial Na/Ca exchanger (NCLX) was essential for Ca homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models.
The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not.
The NCLX may be necessary but is not sufficient for Ca homeostasis and viability.
Luongo 等人发现线粒体 Na/Ca 交换器（NCLX）对于钙稳态和生存能力至关重要。在这里，我们根据分形自相似性和定量差异（QD）重新分析他们的数据。我们计算了 NCLX 条件性功能丧失型小鼠模型的 7 维数据，以及 NCLX 过表达（NCLX-Tg）模型的 9 维数据。
NCLX-Tg 及其 tTA 对照的 9 维数据部分相互自相似，而 NCLX 敲除模型的 7 维数据则不然。
NCLX 对于钙稳态和生存能力可能是必要的，但不是充分的。
