Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Brain Behav. 2018 Oct;8(10):e01114. doi: 10.1002/brb3.1114. Epub 2018 Sep 3.
High levels of mean platelet volume (MPV) had been found in depression subjects. We sought to examine the relationship between MPV and poststroke depression (PSD).
One hundred and eighty-five patients with acute ischemic stroke were enrolled in our study. Peripheral venous blood samples were drawn at admission and MPV levels were measured by the automated hematology analyzer. Patients with a HAMD-17 score >7 were diagnosed as having PSD.
We found that 60 patients (32.4%) developed PSD, the MPV levels in PSD patients were significantly higher (9.3 ± 1.8 fl) compared to non-PSD patients (8.5 ± 1.6 fl). High MPV levels (≥9.1 fl) were independently correlated with PSD (OR 2.762, 95% CI 1.138-6.702, p = 0.025).
Patients with higher levels of MPV at admission were correlated with the development of PSD at 1 month after stroke and might be a predictor of its presence.
已有研究发现，抑郁症患者的平均血小板体积（MPV）水平较高。本研究旨在探讨血小板体积与卒中后抑郁（PSD）的关系。
本研究纳入 185 例急性缺血性脑卒中患者。入院时采集外周静脉血样，采用自动化血液分析仪检测血小板体积水平。汉密尔顿抑郁量表 17 项评分（HAMD-17）＞7 分的患者被诊断为 PSD。
我们发现，60 例（32.4%）患者发生 PSD，PSD 患者的血小板体积水平明显高于非 PSD 患者（9.3±1.8fl 比 8.5±1.6fl）。高水平的血小板体积（≥9.1fl）与 PSD 独立相关（OR 2.762，95%CI 1.138-6.702，p=0.025）。
入院时血小板体积水平较高的患者与卒中后 1 个月 PSD 的发生相关，可能是 PSD 的预测指标。
