Tuszynski Jack A, Sataric Miljko V, Sekulic Dalibor L, Sataric Bogdan M, Zdravkovic Slobodan
Department of Physics, University of Alberta, Edmonton, Alberta, Canada; Department of Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada; Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Torino, Italy.
University of Novi Sad, Faculty of Technical Sciences, Novi Sad, Serbia.
Biosystems. 2018 Nov;173:181-190. doi: 10.1016/j.biosystems.2018.08.006. Epub 2018 Sep 1.
Calcium ions (Ca) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair-bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca ions inside stereocilia. We showed how this can be utilized for tuning of force-generating myosin motors. In an established model, we unified the Ca nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair-bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca ions in the regulation of processes in the auditory cells of the inner ear.
钙离子（Ca）调节和控制耳蜗及前庭生理过程的众多不同方面。本文聚焦于内耳毛束中肌动蛋白丝的聚电解质特性背景下，钙离子对感觉毛细胞机械转导的控制。这些肌动蛋白丝似乎是钙离子在静纤毛内流动的有效途径。我们展示了如何利用这一点来调节产生力的肌球蛋白马达。在一个既定模型中，我们将控制肌球蛋白适应马达的钙离子非线性动力学与毛束的机械位移统一起来。该模型表明，特征时间尺度与内耳自发振荡的现有实验数据相当吻合。这种情况有望填补我们对内耳听觉细胞中钙离子在调节过程中作用理解上的空白。
