用于多巴胺转运体功能和调节分析的模型系统。
Model systems for analysis of dopamine transporter function and regulation.
机构信息
Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, 58202, USA.
Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, ND, 58202, USA.
出版信息
Neurochem Int. 2019 Feb;123:13-21. doi: 10.1016/j.neuint.2018.08.015. Epub 2018 Sep 1.
Abstract
The dopamine transporter (DAT) plays a critical role in dopamine (DA) homeostasis by clearing transmitter from the extraneuronal space after vesicular release. DAT serves as a site of action for a variety of addictive and therapeutic reuptake inhibitors, and transport dysfunction is associated with transmitter imbalances in disorders such as schizophrenia, attention deficit hyperactive disorder, bipolar disorder, and Parkinson disease. In this review, we describe some of the model systems that have been used for in vitro analyses of DAT structure, function and regulation, and discuss a potential relationship between transporter kinetic values and membrane cholesterol.
摘要
多巴胺转运体（DAT）在多巴胺（DA）稳态中发挥着关键作用，它可以在囊泡释放后清除细胞外空间中的递质。DAT 是多种成瘾性和治疗性再摄取抑制剂的作用部位，转运功能障碍与精神分裂症、注意缺陷多动障碍、双相情感障碍和帕金森病等疾病中的递质失衡有关。在这篇综述中，我们描述了一些用于 DAT 结构、功能和调节的体外分析的模型系统，并讨论了转运体动力学值与膜胆固醇之间的潜在关系。
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