Centre for Psychiatry Research, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.
J Nucl Med. 2010 Sep;51(9):1331-4. doi: 10.2967/jnumed.109.065656. Epub 2010 Aug 18.
The dopamine transporter (DAT) is a transmembrane protein responsible for reuptake of dopamine from the synaptic cleft and termination of dopaminergic transmission. Several radioligands are available for DAT imaging with SPECT and PET. This review summarizes the main SPECT and PET radioligands and the main applications of DAT imaging in neuropsychiatric disorders.
多巴胺转运体(DAT)是一种跨膜蛋白,负责从突触间隙重摄取多巴胺并终止多巴胺能传递。有几种放射性配体可用于 SPECT 和 PET 中的 DAT 成像。本文综述了主要的 SPECT 和 PET 放射性配体以及 DAT 成像在神经精神疾病中的主要应用。