Departments of Gastroenterology, Aichi Medical University, Nagakute, Japan.
Departments of Gastroenterology, Aichi Medical University, Nagakute,
Digestion. 2019;99(2):157-165. doi: 10.1159/000490790. Epub 2018 Sep 4.
Combined 24-h intraesophageal pH-multichannel intraluminal impedance (24MII-pH) used for assessing gastroesophageal reflux disease by measuring baseline impedance (BI) requires a 24-h measuring period. In the present study, we developed a quick method of measuring BI and evaluated its usefulness in classifying patients with proton pump inhibitor (PPI)-refractory non-erosive reflux diseases (NERD) as having functional heartburn (FH) or endoscopic-negative reflux disease (ENRD).
Ninety-one NERD patients without esophageal motility disorder underwent 24MII-pH monitoring while on a PPI. The measurements of the mean nocturnal BI (MNBI) and short MNBI were assessed at 3 times (at about 1: 00, 2: 00, and 3: 00 am) for 10 min and 30 s respectively. The measurement of the simple mean BI (MBI) was performed once 30 s at about 11: 00 am.
Ninety-one patients were divided into 2 groups: 59 with ENRD and 32 with FH. The cutoff, specificity, and sensitivity for distinguishing patients with FH were as follows: MNBI, 2,874.1 Ω, 72%, and 72%; short MNBI, 2,857.6 Ω, 74%, and 84%; and simple MBI, 2,874.1 Ω, 86%, and 78% respectively.
Measuring the simple MBI is a quick method and is useful for distinguishing patients with FH from those in a cohort with PPI-refractory NERD.
通过测量基线阻抗（BI）来评估胃食管反流病的联合 24 小时食管内 pH-多通道腔内阻抗（24MII-pH）需要 24 小时的测量时间。在本研究中，我们开发了一种快速测量 BI 的方法，并评估其在分类质子泵抑制剂（PPI）难治性非糜烂性反流病（NERD）患者中是否具有功能性烧心（FH）或内镜阴性反流病（ENRD）的有用性。
91 例无食管动力障碍的 NERD 患者在服用 PPI 时接受 24MII-pH 监测。分别在 1:00、2:00 和 3:00 左右测量 10 分钟和 30 秒的平均夜间 BI（MNBI）和短 MNBI，在 11:00 左右测量 30 秒的简单平均 BI（MBI）。
91 例患者分为 2 组：59 例为 ENRD，32 例为 FH。区分 FH 患者的截断值、特异性和敏感性如下：MNBI，2874.1 Ω，72%和 72%；短 MNBI，2857.6 Ω，74%和 84%；简单 MBI，2874.1 Ω，86%和 78%。
测量简单 MBI 是一种快速的方法，可用于区分 PPI 难治性 NERD 患者中的 FH 患者。
