Zuckerman-Levin Nehama, Dabaja-Younis Haleema, Ameer Elemy, Cohen Michal, Maor Yasmin, Shehadeh Naim
Pediatric Diabetes Unit, Endocrinology, Diabetes, and Metabolism Institute, Rambam Health Care Campus, Haifa, Israel.
The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Rambam Maimonides Med J. 2018 Sep 2;9(4):1-8. doi: 10.5041/RMMJ.10350.
Research and theory suggests that socioeconomic status may affect diabetes control. We investigated the effect of socioeconomic status and ethnicity on glycated hemoglobin (HbA1c) in Arab and Jewish children with type 1 diabetes mellitus in northern Israel.
Data were collected from medical records of 80 Arab and 119 Jewish children attending a pediatric diabetes clinic in a tertiary health care center. Multivariate regression analysis was used to assess factors independently affecting HbA1c level.
Mean age was 12.9±4.7 years. Arab families had more children compared to Jewish families (3.7±1.5 versus 2.9±1.2, respectively, P=0.0007). Academic education was significantly less common in Arab families (25% versus 66.2%, respectively, P=0.0001). Income of Jewish parents was significantly higher compared to that of Arab parents (7,868±2,018 versus 5,129±906 NIS/month, respectively, P=0.0001). Mean age at diagnosis of diabetes was 9.6±4.6 years and disease duration was 3.4±2.3 years in both groups. Half of Arab and Jewish children were treated with multiple insulin injections and half with insulin pumps. Mean number of self-glucose testing/day was higher in Jewish children than in Arab children (4.7±2.5 versus 4.0±1.5, respectively, P=0.033). Mean HbA1c was above recommendations, 9.5% (12.6 mmol/L) in Arab children and 8.7% (11.3 mmol/L) in Jewish children (P=0.004). In multivariate analysis, disease duration (P=0.010) and ethnicity (P=0.034 for Arabs versus Jews) were independently associated with HbA1c.
Both Arab and Jewish children failed to meet HbA1c goals, but this effect was significantly greater for Arabs. Ethnicity remained a predictor of failure even following adjustment for potential confounders.
研究与理论表明社会经济地位可能影响糖尿病控制。我们调查了社会经济地位和种族对以色列北部患1型糖尿病的阿拉伯和犹太儿童糖化血红蛋白(HbA1c)的影响。
从一家三级医疗保健中心的儿科糖尿病诊所的80名阿拉伯儿童和119名犹太儿童的病历中收集数据。采用多变量回归分析来评估独立影响HbA1c水平的因素。
平均年龄为12.9±4.7岁。与犹太家庭相比,阿拉伯家庭的子女更多(分别为3.7±1.5和2.9±1.2,P = 0.0007)。阿拉伯家庭中接受过高等教育的情况明显较少(分别为25%和66.2%,P = 0.0001)。犹太父母的收入明显高于阿拉伯父母(分别为7868±2018和5129±906新谢克尔/月,P = 0.0001)。两组糖尿病诊断时的平均年龄为9.6±4.6岁,病程为3.4±2.3年。一半的阿拉伯和犹太儿童接受多次胰岛素注射治疗,另一半使用胰岛素泵治疗。犹太儿童每天自我血糖检测的平均次数高于阿拉伯儿童(分别为4.7±2.5和4.0±1.5,P = 0.033)。平均HbA1c高于推荐值,阿拉伯儿童为9.5%(12.6 mmol/L),犹太儿童为8.7%(11.3 mmol/L)(P = 0.004)。在多变量分析中,病程(P = 0.010)和种族(阿拉伯人与犹太人相比,P = 0.034)与HbA1c独立相关。
阿拉伯和犹太儿童均未达到HbA1c目标,但这种影响在阿拉伯儿童中明显更大。即使在对潜在混杂因素进行调整后,种族仍然是未达目标的一个预测因素。