Krstić R
J Neural Transm Suppl. 1986;21:415-32.
On the basis of conventional transmission electron microscopy and ultracytochemical reactions for demonstration of calcium, for glucose-6-phosphatase, and for Ca2+-ATPase, intracellular and extracellular mineralization foci in the superficial pineal gland of the Mongolian gerbil (Meriones unguiculatus) have been described. The initial intracellular calcification sites occur in the cytoplasmic matrix, vacuoles, mitochondria and the endoplasmic reticulum of large clear pinealocytes. These loci, and particularly those within the cytoplasmic matrix, transform into acervuli by a further addition of hydroxyapatite crystals. The cells gradually degenerate, die, break down, and the acervuli reach the extracellular space. It has been suggested that the reason for a rise in intracellular calcium levels could be the incapacity of Ca2+-ATPase to eliminate this cation from the cell, so that the hypercalcemic intracellular milieu becomes favourable for the initial crystallization. The primary extracellular mineralization sites occur in the calcium-rich flocculent material. The mineralization process in the gerbil pineal gland is interpreted as a histophysiological phenomenon intimately related to the metabolic activity of the pineal gland.
基于用于显示钙、葡萄糖-6-磷酸酶和Ca2+-ATP酶的传统透射电子显微镜和超微细胞化学反应，已描述了长爪沙鼠（Meriones unguiculatus）松果体浅层的细胞内和细胞外矿化灶。最初的细胞内钙化位点出现在大型透明松果体细胞的细胞质基质、液泡、线粒体和内质网中。这些位点，尤其是细胞质基质中的位点，通过进一步添加羟基磷灰石晶体而转变为凝聚物。细胞逐渐退化、死亡、分解，凝聚物到达细胞外空间。有人认为细胞内钙水平升高的原因可能是Ca2+-ATP酶无法将这种阳离子从细胞中清除，因此细胞内高钙环境有利于初始结晶。主要的细胞外矿化位点出现在富含钙的絮状物质中。沙鼠松果体中的矿化过程被解释为一种与松果体代谢活动密切相关的组织生理现象。
