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经过基因工程改造以过度表达生长因子的人脐带血间充质干细胞可加速头发生长效果。

Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth.

作者信息

Bak Dong Ho, Choi Mi Ji, Kim Soon Re, Lee Byung Chul, Kim Jae Min, Jeon Eun Su, Oh Wonil, Lim Ee Seok, Park Byung Cheol, Kim Moo Joong, Na Jungtae, Kim Beom Joon

机构信息

Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 06973, Korea.

Department of Medicine, Graduate School, Chung-Ang University, Seoul 06973, Korea.

出版信息

Korean J Physiol Pharmacol. 2018 Sep;22(5):555-566. doi: 10.4196/kjpp.2018.22.5.555. Epub 2018 Aug 27.

DOI:10.4196/kjpp.2018.22.5.555
PMID:30181702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6115345/
Abstract

Human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) are used in tissue repair and regeneration; however, the mechanisms involved are not well understood. We investigated the hair growth-promoting effects of hUCB-MSCs treatment to determine whether hUCB-MSCs enhance the promotion of hair growth. Furthermore, we attempted to identify the factors responsible for hair growth. The effects of hUCB-MSCs on hair growth were investigated , and hUCB-MSCs advanced anagen onset and hair follicle neogeneration. We found that hUCB-MSCs co-culture increased the viability and up-regulated hair induction-related proteins of human dermal papilla cells (hDPCs) . A growth factor antibody array revealed that secretory factors from hUCB-MSCs are related to hair growth. Insulin-like growth factor binding protein-1 (IGFBP-1) and vascular endothelial growth factor (VEGF) were increased in co-culture medium. Finally, we found that IGFBP-1, through the co-localization of an IGF-1 and IGFBP-1, had positive effects on cell viability; VEGF secretion; expression of alkaline phosphatase (ALP), CD133, and β-catenin; and formation of hDPCs 3D spheroids. Taken together, these data suggest that hUCB-MSCs promote hair growth via a paracrine mechanism.

摘要

人脐带血间充质干细胞（hUCB-MSCs）用于组织修复和再生；然而，其中涉及的机制尚未完全清楚。我们研究了hUCB-MSCs治疗促进头发生长的作用，以确定hUCB-MSCs是否能增强对头发生长的促进作用。此外，我们试图确定对头发生长负责的因素。研究了hUCB-MSCs对头发生长的影响，发现hUCB-MSCs可提前生长期开始并促进毛囊新生。我们发现hUCB-MSCs共培养可提高人真皮乳头细胞（hDPCs）的活力并上调与毛发诱导相关的蛋白。生长因子抗体阵列显示，hUCB-MSCs的分泌因子与头发生长有关。共培养基中胰岛素样生长因子结合蛋白-1（IGFBP-1）和血管内皮生长因子（VEGF）增加。最后，我们发现IGFBP-1通过IGF-1与IGFBP-1的共定位，对细胞活力、VEGF分泌、碱性磷酸酶（ALP）、CD133和β-连环蛋白的表达以及hDPCs三维球体的形成具有积极作用。综上所述，这些数据表明hUCB-MSCs通过旁分泌机制促进头发生长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/2a85f0b898ca/kjpp-22-555-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/6d9c9667c104/kjpp-22-555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/640ec6779a21/kjpp-22-555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/90924267af31/kjpp-22-555-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/e384bc375a8f/kjpp-22-555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/2a85f0b898ca/kjpp-22-555-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/6d9c9667c104/kjpp-22-555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/640ec6779a21/kjpp-22-555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/90924267af31/kjpp-22-555-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/e384bc375a8f/kjpp-22-555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8309/6115345/2a85f0b898ca/kjpp-22-555-g005.jpg

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