Nayak Mayur, Nag H L, Gaba Sahil, Nag T C, Sharma Saurabh
Department of Orthopaedics, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
J Orthop Traumatol. 2018 Jul 18;19(1):5. doi: 10.1186/s10195-018-0498-7.
Proprioception is a specialized sensory modality encompassing the movement of the joint and its position in space. Reconstruction of the anterior cruciate ligament (ACL) does not always yield expected outcome, suggesting that successful reconstruction depends on not only the ultimate strength of the graft but also recovery of proprioception. Treatment delay is a significant concern in developing countries, e.g., in Asia. Thus, presence of mechanoreceptors is one of the factors having paramount importance for successful outcome. We conducted this study to identify mechanoreceptors via immunohistochemical staining and correlate their presence with duration of injury.
A total of 38 injured native ACL stumps were harvested from patients undergoing ACL reconstruction and stained with neurofilament protein stain to detect functional mechanoreceptors.
Of the specimens, 44.7% stained positive for monoclonal antibody. No association was found between duration of injury and presence of mechanoreceptors (p = 0.897). No correlation was seen between age and side.
No correlation was found between duration of injury and presence of viable mechanoreceptors, hence it is beneficial to preserve the native ACL stump irrespective of the time interval between injury and surgery.
III.
本体感觉是一种特殊的感觉模式，包括关节的运动及其在空间中的位置。前交叉韧带（ACL）重建并不总是能产生预期的结果，这表明成功的重建不仅取决于移植物的最终强度，还取决于本体感觉的恢复。治疗延迟在发展中国家（如亚洲）是一个重大问题。因此，机械感受器的存在是成功治疗结果的最重要因素之一。我们进行这项研究是为了通过免疫组织化学染色鉴定机械感受器，并将它们的存在与损伤持续时间相关联。
从接受ACL重建的患者中收集了38个受伤的天然ACL残端，并用神经丝蛋白染色剂进行染色，以检测功能性机械感受器。
在这些标本中，44.7%对单克隆抗体染色呈阳性。未发现损伤持续时间与机械感受器的存在之间存在关联（p = 0.897）。年龄与患侧之间未发现相关性。
未发现损伤持续时间与存活的机械感受器的存在之间存在相关性，因此无论损伤与手术之间的时间间隔如何，保留天然ACL残端都是有益的。
III级。
