a Department of Physiology, Physiology , ACS Medical College and Hospital, Vellapanchavadi , Chennai , India.
b Physiology , Chettinad Hospital and Research Institute , Chennai , India.
Clin Exp Hypertens. 2019;41(4):394-399. doi: 10.1080/10641963.2018.1510942. Epub 2018 Sep 5.
Over the recent years, the pathophysiology of the inflammatory component in hypertension has been a challenge, because this inflammatory response is mainly contributed by an increased oxidative stress with the release of inflammatory mediators. Identification of a simple and early inflammatory marker such as the neutrophil-to-lymphocyte ratio (NLR) is the need of the hour. This study correlates the same specifically taking into account the duration and the grades of hypertension.
The response of the NLR among the hypertensives and its correlation with duration and stages of hypertension.
Totally, 80 subjects and 40 controls of age between 20 and 60 years and both genders were included. Three recordings of blood pressure were measured with a standard mercury sphygmomanometer. The differential leukocyte count was estimated with an automated Beckman Coulter.
Variations in the neutrophil and lymphocyte counts were significant among the hypertensives with a p-value < 0.001. The NLR was also significantly altered among the hypertensives with a p-value = 0.001. The NLR showed a rise in value among the normotensives, prehypertensives, and stage 1 of systolic hypertension, though not statistically significant. An increase in the NLR was observed in hypertensives with duration of 1-2 years.
Our study gives a new insight with a rise in NLR in early years and even among prehypertensives and stage 1 systolic hypertension under strict criterion. This could be utilized as an early predictive tool, relating the inflammatory process and hypertension which on further intervention could slow the progression of the disease process.
NLR: Neutrophil-to-lymphocyte ratio; BP: Blood pressure.
研究高血压患者中性粒细胞与淋巴细胞比值（NLR）的变化及其与高血压持续时间和分期的相关性。
共纳入 80 例年龄在 20 至 60 岁之间的高血压患者和 40 例年龄匹配的健康对照者，使用标准的汞柱血压计测量三次血压，使用自动贝克曼库尔特（Beckman Coulter）仪器检测白细胞分类计数。
高血压患者的中性粒细胞和淋巴细胞计数有显著变化（p 值均＜0.001），NLR 也有显著变化（p 值=0.001）。在正常血压者、高血压前期者和收缩压 1 期高血压者中，NLR 值略有升高，但无统计学意义。在持续 1-2 年的高血压患者中，NLR 升高。
我们的研究提供了一个新的视角，即在严格的标准下，NLR 在高血压早期、甚至在高血压前期和收缩压 1 期高血压中升高。这可能成为一种早期预测工具，与高血压的炎症过程相关，进一步的干预可能会减缓疾病进程。
NLR：中性粒细胞与淋巴细胞比值；BP：血压。
