Kılıçaslan Barış, Dursun Hüseyin, Kaymak Sermin, Aydın Mehmet, Ekmekçi Cenk, Susam İbrahim, Özdoğan Öner
Department of Cardiology, İzmir Tepecik Training and Research Hospital, İzmir, Turkey.
Department of Internal Medicine, İzmir Tepecik Training and Research Hospital, İzmir, Turkey.
Turk Kardiyol Dern Ars. 2015 Jan;43(1):18-24. doi: 10.5543/tkda.2015.10594.
Blood pressure (BP) variability is associated with hypertensive (HT) target organ damage and cardiovascular events. The aim of this study was to investigate the relation between neutrophil to lymphocyte ratio (NLR) and BP variability in hypertensive and normotensive subjects.
In this cross-sectional study, 150 subjects (63 male, mean age 52.1±5.2 years) were enrolled. In all patients, blood samples and 24-hour ambulatory blood pressure (BP) monitoring were obtained. According to 24-hour ambulatory BP results, participants were divided into four investigation categories. Group 1= Normotensive dipper (ND), Group 2= Normotensive non-dipper (NN), Group 3= HT dipper (HD), Group 4= HT non-dipper (HN).
Highest NLR values were determined in the HN group (p=0.005 vs. ND, p=0.046 vs. NN and p<0.01 vs. HD). NLR values were similar among the ND, NN and HD groups (p>0.05, for all). NLR was correlated with night systolic blood pressure (SBP) (r=0.178, p=0.031), night diastolic blood pressure (DBP) (r=0.176, p=0.032) and BP variation rate (r=-0.246, p=0.003). Multiple linear regression analysis showed BP variation rate to be an independent predictor of high NLR value (ß=0.186, 95% CI=0.918-0.982, p=0.044). In ROC analysis, a level of NLR>2.7 predicted non-dipper HT with 83% sensitivity and 65% specificity (ROC area under curve: 0.653, 95% CI=0.565-0.741, p=0.001).
In the present study, we found that NLR levels were significantly correlated with BP variability. The measurement of NLR may be used to indicate increased risk of HT-related adverse cardiovascular events.
血压（BP）变异性与高血压（HT）靶器官损害及心血管事件相关。本研究旨在探讨高血压和血压正常受试者中性粒细胞与淋巴细胞比值（NLR）与BP变异性之间的关系。
在这项横断面研究中，纳入了150名受试者（63名男性，平均年龄52.1±5.2岁）。所有患者均采集了血样并进行了24小时动态血压（BP）监测。根据24小时动态血压结果，将参与者分为四个调查类别。第1组=血压正常勺型（ND），第2组=血压正常非勺型（NN），第3组=高血压勺型（HD），第4组=高血压非勺型（HN）。
HN组的NLR值最高（与ND组相比，p = 0.005；与NN组相比，p = 0.046；与HD组相比，p < 0.01）。ND、NN和HD组之间的NLR值相似（所有p>0.05）。NLR与夜间收缩压（SBP）（r = 0.178，p = 0.031）、夜间舒张压（DBP）（r = 0.176，p = 0.032）和血压变异性率（r = -0.246，p = 0.003）相关。多元线性回归分析显示血压变异性率是高NLR值的独立预测因素（β = 0.186，95%CI = 0.918 - 0.982，p = 0.044）。在ROC分析中，NLR>2.7可预测非勺型高血压，敏感性为83%，特异性为65%（曲线下面积：0.653，95%CI = 0.565 - 0.741，p = 0.001）。
在本研究中，我们发现NLR水平与BP变异性显著相关。NLR的测量可用于指示HT相关不良心血管事件风险增加。
