撒丁岛两个X连锁基因的连锁不平衡及其对人类X染色体统计定位的影响。
Linkage disequilibrium for two X-linked genes in Sardinia and its bearing on the statistical mapping of the human X chromosome.
作者信息
Filippi G, Rinaldi A, Palmarino R, Seravalli E, Siniscalco M
出版信息
Genetics. 1977 May;86(1):199-212. doi: 10.1093/genetics/86.1.199.
Abstract
The distribution of four X-linked mutants (G6PD, Deutan, Protan and Xg) among lowland and once highly malarial populations of Sardinia discloses a clear-cut example of linkage disequiligrium between two of them (G6PD and Protan). In the same populations the distribution of G6PD-deficiency versus colorblindness of the Deutan type and the Xg blood-group is not significantly different from that expected at equilibrium. These data suggest indirectly that the loci for G6PD and Protan may be nearer to one another than those for G6PD and Deutan.
摘要
四种X连锁突变体（葡萄糖-6-磷酸脱氢酶、绿色盲、红色盲和Xg血型）在撒丁岛的低地人群和曾经疟疾高发的人群中的分布情况，揭示了其中两种突变体（葡萄糖-6-磷酸脱氢酶和红色盲）之间存在明显的连锁不平衡实例。在相同人群中，葡萄糖-6-磷酸脱氢酶缺乏症与绿色盲型色盲及Xg血型的分布与平衡状态下预期的分布并无显著差异。这些数据间接表明，葡萄糖-6-磷酸脱氢酶和红色盲的基因座可能比葡萄糖-6-磷酸脱氢酶和绿色盲的基因座彼此之间靠得更近。
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