一种快速生长的人类甲型肝炎病毒株的初步特性分析。
Preliminary characterization of a fast-growing strain of human hepatitis A virus.
作者信息
Divizia M, Ruggeri F, Hentschel J, Flehmig B, Panà A, Perez-Bercoff R
出版信息
Microbiologica. 1986 Jul;9(3):269-78.
PMID:3018450
Abstract
A fast-growing strain of Human Hepatitis A (HHA) virus was selected by progressively shortening by the time between serial passages of the isolate in the simian cell line Frp/3. The virus so selected infected 90-95% of the cells in 7-10 days, and developed a strong cytopathic effect (CPE). The synthesis of HHA-specific antigens and the CPE were neutralized simultaneously by standard anti-HHA sera. This fast-growing strain has the characteristics of a picornavirus.
摘要
通过逐步缩短分离株在猴肾细胞系Frp/3中的连续传代间隔时间，筛选出一株生长迅速的人甲型肝炎（HHA）病毒。如此筛选出的病毒在7 - 10天内可感染90% - 95%的细胞，并产生强烈的细胞病变效应（CPE）。HHA特异性抗原的合成及CPE可被标准抗HHA血清同时中和。这种生长迅速的毒株具有微小核糖核酸病毒的特征。
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