State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China.
Mil Med Res. 2018 Sep 6;5(1):30. doi: 10.1186/s40779-018-0176-3.
AEOL-10150 is a broad-spectrum metalloporphyrin superoxidase dismutase (SOD) mimic specifically designed to neutralize reactive oxygen and nitrogen species. Research has shown that AEOL-10150 is a potent medical countermeasure against national security threats including sulfur mustard (SM), nerve agent exposure and radiation pneumonitis following a radiological/nuclear incident sufficient to cause acute radiation syndrome (ARS). AEOL-10150 performed well in animal safety studies, and two completed phase 1 safety studies in patients demonstrated that the drug was safe and well tolerated, indicating that AEOL-10150 has potential as a new catalytic antioxidant drug. In this article, we review improvements in AEOL-10150 in preclinical pharmacodynamic studies, especially regarding anti-SM, chlorine gas and radiation exposure studies.
AEOL-10150 是一种广谱金属卟啉超氧化物歧化酶（SOD）模拟物，专门设计用于中和活性氧和氮物种。研究表明，AEOL-10150 是一种有效的医疗对策，可以对抗包括芥子气（SM）在内的国家安全威胁，以及放射性/核事件引起的辐射性肺炎，足以导致急性辐射综合征（ARS）。AEOL-10150 在动物安全性研究中表现良好，两项已完成的患者 1 期安全性研究表明，该药物安全且耐受性良好，表明 AEOL-10150 具有作为新型催化抗氧化药物的潜力。在本文中，我们回顾了 AEOL-10150 在临床前药效学研究中的改进，特别是在抗 SM、氯气和辐射暴露研究方面。
