Department of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China.
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.
Small. 2018 Mar;14(13):e1703736. doi: 10.1002/smll.201703736. Epub 2018 Feb 9.
Catalytic nanomaterials can be used extrinsically to combat diseases associated with a surplus of reactive oxygen species (ROS). Rational design of surface morphologies and appropriate doping can substantially improve the catalytic performances. In this work, a class of hollow polyvinyl pyrrolidone-protected PtPdRh nanocubes with enhanced catalytic activities for in vivo free radical scavenging is proposed. Compared with Pt and PtPd counterparts, ternary PtPdRh nanocubes show remarkable catalytic properties of decomposing H O via enhanced oxygen reduction reactions. Density functional theory calculation indicates that the bond of superoxide anions breaks for the energetically favorable status of oxygen atoms on the surface of PtPdRh. Viability of cells and survival rate of animal models under exposure of high-energy γ radiation are considerably enhanced by 94% and 50% respectively after treatment of PtPdRh nanocubes. The mechanistic investigations on superoxide dismutase (SOD) activity, malondialdehyde amount, and DNA damage repair demonstrate that hollow PtPdRh nanocubes act as catalase, peroxidase, and SOD analogs to efficiently scavenge ROS.
催化纳米材料可以被外源性地用于治疗与活性氧（ROS）过剩相关的疾病。通过合理设计表面形态和适当掺杂，可以显著提高催化性能。在这项工作中，提出了一类具有增强的体内自由基清除催化活性的空心聚乙烯吡咯烷酮保护的 PtPdRh 纳米立方体形貌。与 Pt 和 PtPd 相比，三元 PtPdRh 纳米立方体形貌通过增强的氧还原反应表现出分解 H2O2 的显著催化性能。密度泛函理论计算表明，超氧阴离子的键断裂是由于 PtPdRh 表面氧原子的能量有利状态。经过 PtPdRh 纳米立方体制备的处理后，高能 γ 射线照射下的细胞活力和动物模型的存活率分别提高了 94%和 50%。超氧化物歧化酶（SOD）活性、丙二醛含量和 DNA 损伤修复的机制研究表明，空心 PtPdRh 纳米立方体形貌作为过氧化氢酶、过氧化物酶和 SOD 类似物，能够有效地清除 ROS。
