Cho Yeoungjee, See Emily J, Htay Htay, Hawley Carmel M, Johnson David W
Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia
Australasian Kidney Trials Network, School of Medicine, University of Queensland, Brisbane, Australia.
Perit Dial Int. 2018 Sep-Oct;38(5):319-327. doi: 10.3747/pdi.2018.00017.
There is a growing, global burden of patients with end-stage kidney disease (ESKD) requiring renal replacement therapy. Although peritoneal dialysis (PD) is considered to be the most cost-effective dialysis modality, its utilization has been declining in some regions. The first year after starting PD is thought to be a vulnerable period for technique failure, which in turn contributes to poor patient retention. Improved understanding of the risk factors for technique failure during this period may help the development of targeted strategies to lower its incidence and improve both the utilization and utility of PD. This up-to-date review will summarize current evidence regarding the definition, incidence, causes, and predictors of early PD technique failure. Promising avenues for directing future research efforts will also be discussed.
需要肾脏替代治疗的终末期肾病（ESKD）患者的全球负担正在不断增加。尽管腹膜透析（PD）被认为是最具成本效益的透析方式，但在某些地区其使用率却在下降。开始PD治疗后的第一年被认为是技术失败的脆弱期，这反过来又导致患者留存率低。更好地了解这一时期技术失败的风险因素可能有助于制定有针对性的策略，以降低其发生率，并提高PD的使用率和效用。这篇最新综述将总结关于早期PD技术失败的定义、发生率、原因和预测因素的现有证据。还将讨论指导未来研究工作的有前景的途径。
