Robertson J B, Williams J R, Little J B
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Jun;31(6):529-39. doi: 10.1080/09553007714550641.
Using colony formation as an assay, a rat-mouse hybrid cell-line (HD1) and one of its parent lines (H4) have been studied as to their abilities to survive exposure to ionizing radiation, ultraviolet light, and the drugs actinomycin D and cordycepin. HD1 cells are more resistant than H4 to ionizing radiation, actinomycin D and cordycepin. Both cell lines respond similarly to ultraviolet light. When both cell-lines were co-treated with actinomycin D or cordycepin, the toxic effect of ionizing radiation was enhanced, whereas that of ultraviolet light (U.V.L.) was unchanged. The data suggest that RNA synthesis is more important immediately after irradiation with X-rays than with U.V.L. and that cells resistant to the toxic effect of ionizing radiation are also resistant to the toxicity induced by inhibitors of RNA synthesis.
以集落形成作为检测方法，对大鼠 - 小鼠杂交细胞系（HD1）及其亲本系之一（H4）进行了研究，以考察它们在受到电离辐射、紫外线以及药物放线菌素D和虫草素作用后的存活能力。HD1细胞比H4细胞对电离辐射、放线菌素D和虫草素更具抗性。两种细胞系对紫外线的反应相似。当两种细胞系同时用放线菌素D或虫草素处理时，电离辐射的毒性作用增强，而紫外线（U.V.L.）的毒性作用不变。数据表明，X射线照射后RNA合成比紫外线照射后更重要，并且对电离辐射毒性作用具有抗性的细胞对RNA合成抑制剂诱导的毒性也具有抗性。
