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经X射线和虫草素处理的同步化V79细胞的存活情况。

Survival of synchronized V79 cells treated with X-rays and cordycepin.

作者信息

Robertson J B, Oleson F B, Williams J R, Little J B

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Jan;31(1):11-6. doi: 10.1080/09553007714550021.

DOI:10.1080/09553007714550021
PMID:300368
Abstract

The survival of V79 Chinese hamster lung cells exposed to X-irradiation is reduced by co-treatment with cordycepin (3'-deoxyadenosine). This reduction is manifested principally by a decrease in the D0 of the X-ray survival curve from 199 rad in untreated cells to 106 rad in cordycepin-treated cells. Reduced survival is seen throughout the life-cycle when synchronized cell populations are exposed to both agents with cells in mid-S being especially sensitive.

摘要

用虫草素(3'-脱氧腺苷)联合处理可降低经X射线照射的V79中国仓鼠肺细胞的存活率。这种降低主要表现为X射线存活曲线的D0值从未处理细胞的199拉德降至虫草素处理细胞的106拉德。当同步化细胞群体同时暴露于这两种试剂时,在整个生命周期中都会出现存活率降低的情况,其中处于S期中期的细胞尤为敏感。

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