哒嗪基 - γ-氨基丁酸衍生物作为猫脊髓中γ-氨基丁酸和甘氨酸拮抗剂
Pyridazinyl-GABA derivatives as GABA and glycine antagonists in the spinal cord of the cat.
作者信息
Gynther B D, Curtis D R
出版信息
Neurosci Lett. 1986 Jul 24;68(2):211-5. doi: 10.1016/0304-3940(86)90144-8.
PMID:3018632
Abstract
Of two arylaminopyridazine derivatives of gamma-aminobutyric acid (GABA) tested as antagonists of the inhibitory actions of glycine and GABA in the spinal cord of pentobarbitone-anaesthetized cats, one - SR95531 - was sufficiently selective to be of use in microelectrophoretic investigations of GABA-mediated synaptic transmission.
摘要
在戊巴比妥麻醉的猫脊髓中，作为甘氨酸和γ-氨基丁酸（GABA）抑制作用拮抗剂进行测试的两种γ-氨基丁酸芳基氨基哒嗪衍生物中，一种——SR95531——具有足够的选择性，可用于GABA介导的突触传递的微电泳研究。
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