Saggau P, Galvan M, ten Bruggencate G
Neurosci Lett. 1986 Aug 15;69(1):53-8. doi: 10.1016/0304-3940(86)90413-1.
Pre- and postsynaptic potential changes evoked by stimulation of the Schaffer collateral-commissural input to CA1 pyramidal neurons were optically recorded in guinea pig hippocampal slices after staining the preparation with a suitable voltage-sensitive fluorescent dye. Brief tetanic stimulation induced long-term potentiation of synaptic transmission as monitored both optically and electrically. The results demonstrate that non-invasive optical techniques can be used to study long-term changes in spatial neuronal interactions, possibly involved in learning and other higher functions of the nervous system.
