Schwark W S, Haluska M
Neurosci Lett. 1986 Aug 15;69(1):65-9. doi: 10.1016/0304-3940(86)90415-5.
A novel, specific inhibitor of gamma-aminobutyric acid (GABA) uptake, SKF 89976-A (N-[4,4-diphenyl-3-butenyl]-nipecotic acid), was administered daily (15 mg/kg, i.p.) 30 min prior to amygdala stimulation in adult female rats. Whereas control rats developed full kindled seizures after 9.4 +/- 1.2 amygdala stimulations. SKF 89976-A-treated rats had not progressed beyond an early stage of kindled seizures by the termination of drug treatment after 22 episodes of daily amygdala stimulation. Following cessation of SKF 89976-A treatment, full kindled seizures developed after 4.1 +/- 0.9 additional amygdala stimuli. The data suggest that SKF 89976-A can inhibit generalization of amygdala-kindled seizures, possibly by enhancement of central GABAergic activity.
一种新型的、特异性的γ-氨基丁酸（GABA）摄取抑制剂SKF 89976-A（N-[4,4-二苯基-3-丁烯基]-哌啶酸），在成年雌性大鼠杏仁核刺激前30分钟每日腹腔注射（15毫克/千克）。对照大鼠在9.4±1.2次杏仁核刺激后出现完全点燃性癫痫发作。在每日杏仁核刺激22次后药物治疗结束时，接受SKF 89976-A治疗的大鼠尚未进展到点燃性癫痫发作的早期阶段。停止SKF 89976-A治疗后，在额外的4.1±0.9次杏仁核刺激后出现完全点燃性癫痫发作。数据表明，SKF 89976-A可能通过增强中枢GABA能活性来抑制杏仁核点燃性癫痫发作的泛化。
