Shin C, Rigsbee L C, McNamara J O
Brain Res. 1986 Nov 29;398(2):370-4. doi: 10.1016/0006-8993(86)91498-8.
We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also suppressed both generalized motor seizures and electrographic after discharges in previously fully kindled animals. These results further support the idea that enhanced GABAergic neurotransmission suppresses both seizures and epileptogenesis. The results also suggest that GVG may be an effective anti-seizure and anti-epileptogenic agent in humans.
我们研究了全身性给予γ-乙烯基γ-氨基丁酸（GVG，一种γ-氨基丁酸（GABA）转氨酶抑制剂）对大鼠癫痫点燃模型的影响。GVG（1200或1500毫克/千克）使点燃发展所需的刺激次数增加了约一倍。GVG还抑制了先前已完全点燃的动物的全身性运动性癫痫发作和脑电图放电后电位。这些结果进一步支持了增强GABA能神经传递可抑制癫痫发作和癫痫发生的观点。结果还表明，GVG可能是一种对人类有效的抗癫痫发作和抗癫痫发生药物。
