Wan Zhigang, Wang Jie, Cao Hui, Wu Lili
Department of Anesthesiology, The First People's Hospital of Wujiang District, Suzhou, Jiangsu 215200, P.R. China.
Exp Ther Med. 2018 Sep;16(3):1743-1746. doi: 10.3892/etm.2018.6355. Epub 2018 Jun 26.
The effects of different doses of dexmedetomidine on analgesic efficacy and inflammatory cytokines in patients with laparoscopic surgery were investigated. A total of 179 laparoscopic patients from March 2015 to May 2017 were enrolled and randomly divided into the control group (group A) and three experimental groups with different doses of dexmedetomidine (group B: 0.25; group C: 0.5 and group D: 1 µg/kg). Results showed that there was no significant difference between the four groups in the operation time, the amount of surgical bleeding and intraoperative fluid infusion. The VAS score of group A was significantly higher than the other three groups. In addition, the VAS score of group D at each time-point was the lowest. There was no significant difference regarding the agitation score and sedation score between group A and group B. Furthermore, the restlessness score and sedation score in group C were significantly lower than those in group A and group B. Next we found that CRP and TNF-α in group A and group B were significantly higher than those in groups C and D. In addition, IL-10 in group D was significantly higher than that in group C. Moreover, patients in group C had the least adverse reaction effects. In conclusion, medium dosage of dexmedetomidine cannot only effectively relieve the pain of laparoscopic patients but also regulate the secretion of inflammatory cytokines.
研究了不同剂量右美托咪定对腹腔镜手术患者镇痛效果及炎性细胞因子的影响。选取2015年3月至2017年5月期间的179例腹腔镜手术患者，将其随机分为对照组（A组）和3个不同剂量右美托咪定实验组（B组：0.25；C组：0.5；D组：1 μg/kg）。结果显示，四组患者在手术时间、术中出血量及术中输液量方面无显著差异。A组视觉模拟评分（VAS）显著高于其他三组。此外，D组各时间点的VAS评分最低。A组与B组在躁动评分和镇静评分方面无显著差异。此外，C组的烦躁评分和镇静评分显著低于A组和B组。接下来发现，A组和B组的C反应蛋白（CRP）和肿瘤坏死因子-α（TNF-α）显著高于C组和D组。此外，D组的白细胞介素-10（IL-10）显著高于C组。而且，C组患者的不良反应最少。综上所述，中等剂量右美托咪定不仅能有效缓解腹腔镜手术患者的疼痛，还能调节炎性细胞因子的分泌。
