Asl Masoud Entezari, Isazadefar Khatereh, Mohammadian Ali, Khoshbaten Manouchehr
Ardebil University of Medical Sciences, Iran.
Middle East J Anaesthesiol. 2011 Feb;21(1):67-70.
Postoperative shivering is one of the common problems following general anesthesia and may lead to multiple complications. The aim of this study was to examine the preventive effects of Ondansetron and Meperidine on postoperative shivering.
This randomized placebo-controlled double blind clinical trial included 90 patients scheduled for elective gynecologic operations, randomly divided to three groups. Ondansetron (4 mg), Meperidine (0.4 mg/kg) and 2 cc normal saline (as a control group) were administered immediately before the induction of anesthesia. Anesthesia induced equivalently for all. Patients were observed in terms of vital signs, side effects and shivering.
Postoperative shivering was observed in 13.3% of patients in Ondansetron group and 20% of Meperidine group, significantly lower than the controls (50%). The reduction of core and dermal temperature during the anesthesia and recovery, changes in systolic and diastolic blood pressure and heart rate were similar in all three groups. The incidence of nausea was similar among the three groups of study while vomiting occurred in 6.7% of the Meperidine group and 3.3% of the controls but none in the patients receiving Ondansetron.
Ondansetron can effectively reduce post operative shivering.
术后寒战是全身麻醉后常见的问题之一，可能导致多种并发症。本研究旨在探讨昂丹司琼和哌替啶对术后寒战的预防作用。
这项随机、安慰剂对照、双盲临床试验纳入了90例计划进行择期妇科手术的患者，随机分为三组。在麻醉诱导前立即给予昂丹司琼（4毫克）、哌替啶（0.4毫克/千克）和2毫升生理盐水（作为对照组）。所有患者的麻醉诱导方式相同。观察患者的生命体征、副作用和寒战情况。
昂丹司琼组13.3%的患者出现术后寒战，哌替啶组为20%，显著低于对照组（50%）。三组患者在麻醉和恢复过程中核心温度和皮温的降低、收缩压和舒张压以及心率的变化相似。三组研究中恶心的发生率相似，而哌替啶组6.7%的患者出现呕吐，对照组为3.3%，接受昂丹司琼的患者未出现呕吐。
昂丹司琼可有效减少术后寒战。
