Chen Hui, Zhu Guangming, Liu Nan, Li Ying, Xia Yonghong
Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, P.R. China.
Department of Critical Care Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
Exp Ther Med. 2018 Sep;16(3):2203-2207. doi: 10.3892/etm.2018.6454. Epub 2018 Jul 17.
Brain permeability imaging techniques are specific for the assessment of blood-brain barrier integrity. The present review article primarily focuses on the application of permeability imaging in cases of ischemic stroke. The permeability maps may be used to predict future hemorrhagic transformation in patients following acute ischemic stroke, that have been treated with tissue plasminogen activator (tPA) or recanalization therapy. The permeability imaging would help make the clinical decision to administer tPA following acute ischemic stroke or not, which is not only due to the current 3-4.5 h time window. Additionally, permeability imaging may also be used to evaluate the collateral circulation in the perfusion and permeability of the ischemic area of the brain.
脑通透性成像技术专门用于评估血脑屏障的完整性。本综述文章主要关注通透性成像在缺血性中风病例中的应用。通透性图谱可用于预测急性缺血性中风患者在接受组织型纤溶酶原激活剂（tPA）或再通治疗后未来发生出血性转化的情况。通透性成像有助于做出急性缺血性中风后是否给予tPA的临床决策，这不仅是因为当前3至4.5小时的时间窗。此外，通透性成像还可用于评估脑缺血区域灌注和通透性中的侧支循环。
