渗透性成像在缺血性卒中中的应用与发展
Applications and development of permeability imaging in ischemic stroke.
作者信息
Chen Hui, Zhu Guangming, Liu Nan, Li Ying, Xia Yonghong
机构信息
Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, P.R. China.
Department of Critical Care Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.
出版信息
Exp Ther Med. 2018 Sep;16(3):2203-2207. doi: 10.3892/etm.2018.6454. Epub 2018 Jul 17.
Abstract
Brain permeability imaging techniques are specific for the assessment of blood-brain barrier integrity. The present review article primarily focuses on the application of permeability imaging in cases of ischemic stroke. The permeability maps may be used to predict future hemorrhagic transformation in patients following acute ischemic stroke, that have been treated with tissue plasminogen activator (tPA) or recanalization therapy. The permeability imaging would help make the clinical decision to administer tPA following acute ischemic stroke or not, which is not only due to the current 3-4.5 h time window. Additionally, permeability imaging may also be used to evaluate the collateral circulation in the perfusion and permeability of the ischemic area of the brain.
摘要
脑通透性成像技术专门用于评估血脑屏障的完整性。本综述文章主要关注通透性成像在缺血性中风病例中的应用。通透性图谱可用于预测急性缺血性中风患者在接受组织型纤溶酶原激活剂（tPA）或再通治疗后未来发生出血性转化的情况。通透性成像有助于做出急性缺血性中风后是否给予tPA的临床决策，这不仅是因为当前3至4.5小时的时间窗。此外，通透性成像还可用于评估脑缺血区域灌注和通透性中的侧支循环。
相似文献
1
Applications and development of permeability imaging in ischemic stroke.渗透性成像在缺血性卒中中的应用与发展
Exp Ther Med. 2018 Sep;16(3):2203-2207. doi: 10.3892/etm.2018.6454. Epub 2018 Jul 17.
2
Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke.急性缺血性脑卒中动脉内脑溶栓的试验设计与报告标准。
Stroke. 2003 Aug;34(8):e109-37. doi: 10.1161/01.STR.0000082721.62796.09. Epub 2003 Jul 17.
3
Effects of tissue plasminogen activator timing on blood-brain barrier permeability and hemorrhagic transformation in rats with transient ischemic stroke.组织型纤溶酶原激活剂给药时间对短暂性脑缺血性中风大鼠血脑屏障通透性及出血性转化的影响
J Neurol Sci. 2014 Dec 15;347(1-2):148-54. doi: 10.1016/j.jns.2014.09.036. Epub 2014 Sep 28.
4
Blood-brain barrier permeability assessed by perfusion computed tomography predicts hemorrhagic transformation in acute reperfusion therapy.灌注 CT 评估的血脑屏障通透性可预测急性再灌注治疗中的出血性转化。
Neurol Sci. 2018 Sep;39(9):1579-1584. doi: 10.1007/s10072-018-3468-1. Epub 2018 Jun 16.
5
Computed Tomography Perfusion Derived Blood-Brain Barrier Permeability Does Not Yet Improve Prediction of Hemorrhagic Transformation.计算机断层扫描灌注衍生的血脑屏障通透性尚未改善对出血性转化的预测。
Cerebrovasc Dis. 2018;45(1-2):26-32. doi: 10.1159/000485043. Epub 2018 Jan 8.
6
Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke.急性缺血性脑卒中患者可见颅内闭塞再通与临床、影像和血栓特征的关系。
JAMA. 2018 Sep 11;320(10):1017-1026. doi: 10.1001/jama.2018.12498.
7
Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy.经典 Wnt 信号通路在缺血性脑卒中后维持血脑屏障完整性，其激活可改善组织型纤溶酶原激活剂治疗效果。
Mol Neurobiol. 2019 Sep;56(9):6521-6538. doi: 10.1007/s12035-019-1539-9. Epub 2019 Mar 9.
8
Permeable Thrombi Are Associated With Higher Intravenous Recombinant Tissue-Type Plasminogen Activator Treatment Success in Patients With Acute Ischemic Stroke.在急性缺血性中风患者中，可渗透血栓与静脉注射重组组织型纤溶酶原激活剂治疗成功率较高相关。
Stroke. 2016 Aug;47(8):2058-65. doi: 10.1161/STROKEAHA.116.013306. Epub 2016 Jun 23.
9
Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice.褪黑素可减轻小鼠缺血性卒中后血脑屏障通透性的增加，并减少组织型纤溶酶原激活剂治疗后的组织出血性转化。
J Pineal Res. 2006 Apr;40(3):242-50. doi: 10.1111/j.1600-079X.2005.00307.x.
10
Transient brain hypothermia reduces the reperfusion injury of delayed tissue plasminogen activator and extends its therapeutic time window in a focal embolic stroke model.短暂性脑低温可减轻延迟性组织型纤溶酶原激活剂再灌注损伤，并延长其在局灶性栓塞性卒中模型中的治疗时间窗。
Brain Res Bull. 2017 Sep;134:85-90. doi: 10.1016/j.brainresbull.2017.07.007. Epub 2017 Jul 11.
引用本文的文献
1
Collateral and permeability imaging derived from dynamic contrast material-enhanced MR angiography in prediction of PH 2 hemorrhagic transformation after acute ischemic stroke: a pilot study.基于动态对比增强磁共振血管成像的侧支循环和通透性成像对急性缺血性脑卒中后 PH2 型出血性转化的预测：一项初步研究。
Neuroradiology. 2021 Sep;63(9):1471-1479. doi: 10.1007/s00234-021-02655-5. Epub 2021 Feb 3.
2
Permeability of the blood-brain barrier through the phases of ischaemic stroke and relation with clinical outcome: protocol for a systematic review.缺血性卒中各阶段血脑屏障的通透性及其与临床结局的关系：一项系统评价方案
BMJ Open. 2020 Sep 18;10(9):e039280. doi: 10.1136/bmjopen-2020-039280.
3
The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target.卒中诱导的血脑屏障破坏：检测技术、机制和治疗靶点的最新进展。
Curr Neuropharmacol. 2020;18(12):1187-1212. doi: 10.2174/1570159X18666200528143301.
本文引用的文献
1
Quantification of blood-brain barrier permeability by dynamic contrast-enhanced NIRS.动态对比增强近红外光谱法定量血脑屏障通透性。
Sci Rep. 2017 May 10;7(1):1702. doi: 10.1038/s41598-017-01922-x.
2
The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant K in cervical cancer is explained by plasma flow rather than vessel permeability.动态对比增强磁共振成像造影剂转移常数K在宫颈癌中的预后价值是由血浆流动而非血管通透性所解释的。
Br J Cancer. 2017 May 23;116(11):1436-1443. doi: 10.1038/bjc.2017.121. Epub 2017 Apr 27.
3
Hemorrhagic Transformations after Thrombectomy: Risk Factors and Clinical Relevance.血栓切除术后的出血性转化：危险因素及临床意义
Cerebrovasc Dis. 2017;43(5-6):294-304. doi: 10.1159/000460265. Epub 2017 Mar 25.
4
DCE-MRI blood-brain barrier assessment in acute ischemic stroke.DCE-MRI 评估急性缺血性脑卒中的血脑屏障通透性。
Neurology. 2017 Jan 31;88(5):433-440. doi: 10.1212/WNL.0000000000003566. Epub 2016 Dec 28.
5
Interrogating the Functional Correlates of Collateralization in Patients with Intracranial Stenosis Using Multimodal Hemodynamic Imaging.使用多模态血流动力学成像探究颅内狭窄患者侧支循环的功能相关性
AJNR Am J Neuroradiol. 2016 Jun;37(6):1132-8. doi: 10.3174/ajnr.A4758. Epub 2016 Apr 7.
6
Dynamic Magnetic Resonance Angiography Provides Collateral Circulation and Hemodynamic Information in Acute Ischemic Stroke.动态磁共振血管造影可提供急性缺血性脑卒中的侧支循环和血流动力学信息。
Stroke. 2016 Feb;47(2):531-4. doi: 10.1161/STROKEAHA.115.010748. Epub 2015 Dec 10.
7
The cortical contrast accumulation from brain computed tomography after endovascular treatment predicts symptomatic hemorrhage.血管内治疗后脑计算机断层扫描的皮质对比积累预测症状性出血。
Eur J Neurol. 2015 Nov;22(11):1453-8. doi: 10.1111/ene.12764. Epub 2015 Jul 1.
8
Comparative Analysis of Different Methods of Ischemia/Reperfusion in Hyperglycemic Stroke Outcomes: Interaction with tPA.高血糖性卒中结局中不同缺血/再灌注方法的比较分析：与组织型纤溶酶原激活剂的相互作用
Transl Stroke Res. 2015 Jun;6(3):171-80. doi: 10.1007/s12975-015-0391-0. Epub 2015 Feb 17.
9
Using standard first-pass perfusion computed tomographic data to evaluate collateral flow in acute ischemic stroke.利用标准的首次通过灌注计算机断层扫描数据评估急性缺血性卒中的侧支循环血流。
Stroke. 2015 Apr;46(4):961-7. doi: 10.1161/STROKEAHA.114.008015. Epub 2015 Feb 10.
10
Permeability Imaging as a Biomarker of Leptomeningeal Collateral Flow in Patients with Intracranial Arterial Stenosis.渗透性成像作为颅内动脉狭窄患者软脑膜侧支血流的生物标志物
Cell Biochem Biophys. 2015 Apr;71(3):1273-9. doi: 10.1007/s12013-014-0343-4.
Zotero 插件