Shibasaki Koji, Yamada Shizuru, Akishita Masahiro, Ogawa Sumito
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Komagane Kogen Ladies Clinic, Nagano, Japan.
J Endocr Soc. 2018 Aug 13;2(9):1040-1049. doi: 10.1210/js.2018-00104. eCollection 2018 Sep 1.
Previous research has shown a positive relationship between plasma leptin and sympathetic nervous activity. High plasma leptin activate inflammatory cytokines and lead to muscle wasting. However, studies have detected low sympathetic nervous activity and high plasma leptin in older adults with muscle wasting, sarcopenia, and frailty. High plasma leptin do not seem to correlate with high sympathetic nervous activity. However, their relationship in older adults remains unclear.
We investigated the relationship between plasma leptin and sympathetic nervous activity in older adults.
We conducted a cross-sectional study and analyzed the results from 69 participants aged ≥75 years. Sympathetic nervous activity was measured by heart rate variability, obtained from 24-hour Holter monitoring. A functional independence measure (FIM) and Barthel index were used to assess physical function.
The plasma leptin was higher in women (men, 3.4 ± 2.8 ng/mL; women, 6.6 ± 6.5 ng/mL; = 0.024). Plasma leptin was negatively and substantially related to the FIM ( = -0.233; = 0.049) and Barthel index ( = -0.298, = 0.018) after adjustment for covariates. However, the data showed no relationship between the plasma leptin and sympathetic nervous activity.
We could not detect an association between sympathetic nervous activity and plasma leptin in older adults. This might suggest a failure of the feedback system of the sympathetic nervous system, leading to muscle wasting in older adults.
先前的研究表明血浆瘦素与交感神经活动之间存在正相关关系。高血浆瘦素会激活炎性细胞因子并导致肌肉萎缩。然而，研究发现，在患有肌肉萎缩、肌少症和虚弱的老年人中，交感神经活动较低而血浆瘦素较高。高血浆瘦素似乎与高交感神经活动无关。然而，它们在老年人中的关系仍不清楚。
我们研究了老年人血浆瘦素与交感神经活动之间的关系。
设计、场所和参与者：我们进行了一项横断面研究，并分析了69名年龄≥75岁参与者的结果。通过24小时动态心电图监测获得的心率变异性来测量交感神经活动。使用功能独立性测量量表（FIM）和巴氏指数来评估身体功能。
女性的血浆瘦素水平较高（男性，3.4±2.8 ng/mL；女性，6.6±6.5 ng/mL；P = 0.024）。在对协变量进行调整后，血浆瘦素与FIM（P = -0.233；P = 0.049）和巴氏指数（P = -0.298，P = 0.018）呈负相关且相关性显著。然而，数据显示血浆瘦素与交感神经活动之间没有关系。
我们在老年人中未检测到交感神经活动与血浆瘦素之间存在关联。这可能表明交感神经系统的反馈系统出现故障，导致老年人肌肉萎缩。
