Barnea E R, Lavy G, Fakih H, Decherney A H
Placenta. 1986 Jul-Aug;7(4):307-13. doi: 10.1016/s0143-4004(86)80148-5.
We have studied the possible function of the placental adrenocorticotrophic hormone-(ACTH-) like substance (PALS) in placental steroidogenesis by measuring oestradiol (E2) and progesterone (P4) in term human placental explants incubated with commercially available porcine ACTH I-39. There was a dose-dependent increase in the E2 and P4 released into the medium at 24 h as compared to controls. At 48 h, no significant effect was noted. Propranolol (10(-5) M) did not block the effect of ACTH on P4 release. The data suggest that ACTH may have a regulatory role on placental steroidogenesis. The possible mechanisms of action of PALS on the placenta and the adrenal are discussed, and the role of PALS in the maintenance of pregnancy and in maternal response to stress is suggested.
我们通过检测足月人胎盘外植体与市售猪促肾上腺皮质激素I - 39孵育后培养基中的雌二醇（E2）和孕酮（P4），研究了胎盘促肾上腺皮质激素（ACTH）样物质（PALS）在胎盘类固醇生成中的可能作用。与对照组相比，在24小时时释放到培养基中的E2和P4呈剂量依赖性增加。在48小时时，未观察到显著影响。普萘洛尔（10(-5) M）并未阻断ACTH对P4释放的作用。数据表明ACTH可能对胎盘类固醇生成具有调节作用。讨论了PALS对胎盘和肾上腺的可能作用机制，并提出了PALS在维持妊娠及母体对应激反应中的作用。
