Tashireva L A, Zavgorodskaya K O, Perelmuter V M
Tsitologiia. 2016;58(12):901-7.
It is well known that inflammatory infiltrates in many cases present in the tumor tissue. In addition, to date, convincing evidence for its predictive value for different types of cancer. To the cells of the adaptive immune system, until recently, received more attention but in the last decade has seen a growing number of publications on the participation of innate immunity in cancer processes. This interest is partly due to the fact that in a separate class of innate lymphoid cells were isolated relatively recently. However, when analyzing the literature becomes apparent lack of information about the significance of lymphocytes in vivo innate immunity in the tumor microenvironment formation, angiogenesis, tumor cells motility acquisition and invasive properties, but also for the prediction of the occurrence other forms of progression. This review attempts to structure the available data on the lymphoid cells of the innate immune system, give the brief descriptive characteristics of each subclass, light the question of plasticity of these cells and interaction with the adaptive immune system. Special attention is given to the analysis of the role of the ILC in reparative regeneration as physiological prototype of events that underlie in tumor progression.
众所周知，肿瘤组织中在许多情况下都会出现炎性浸润。此外，迄今为止，尚无关于其对不同类型癌症具有预测价值的确凿证据。对于适应性免疫系统的细胞，直到最近才受到更多关注，但在过去十年中，关于先天免疫参与癌症进程的出版物数量不断增加。这种兴趣部分归因于相对较新分离出一类单独的先天淋巴细胞这一事实。然而，在分析文献时，明显缺乏关于体内先天免疫淋巴细胞在肿瘤微环境形成、血管生成、肿瘤细胞获得运动性和侵袭性特性方面的重要性的信息，以及在预测其他形式进展发生方面的信息。本综述试图梳理关于先天免疫系统淋巴细胞的现有数据，给出每个亚类的简要描述性特征，阐明这些细胞的可塑性问题以及与适应性免疫系统的相互作用。特别关注对先天淋巴细胞在修复性再生中作为肿瘤进展基础事件的生理原型的作用的分析。
