固有淋巴细胞与环境交界表面的癌症。

Innate lymphoid cells and cancer at border surfaces with the environment.

机构信息

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, 10117 Berlin, Germany; Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Charitéplatz 1, 10117 Berlin, Germany.

出版信息

Semin Immunol. 2019 Feb;41:101278. doi: 10.1016/j.smim.2019.06.001. Epub 2019 Aug 28.

DOI:10.1016/j.smim.2019.06.001

PMID:31473072

Abstract

Innate lymphoid cells (ILC) are a recently identified group of innate lymphocytes. ILC are subdivided into cytotoxic ILC (i.e., conventional natural killer (NK) cells) and helper ILC. Helper ILC are tissue-resident cells that have been involved in various physiological and pathological processes of organs and tissues. While their roles during inflammation are well studied, their contribution to tumor immunity is not well known. Here, we will provide an overview of the various helper ILC subsets, their development and function and discuss their potential roles during tumorigenesis and for anti-tumor immunity at border surface with the environment.

摘要

先天淋巴细胞 (ILC) 是最近被鉴定的一组先天淋巴细胞。ILC 可进一步分为细胞毒性 ILC（即常规自然杀伤 (NK) 细胞）和辅助性 ILC。辅助性 ILC 是组织驻留细胞，参与了器官和组织的各种生理和病理过程。虽然它们在炎症过程中的作用已得到充分研究，但它们对肿瘤免疫的贡献尚不清楚。在这里，我们将概述各种辅助性 ILC 亚群的特征、它们的发育和功能，并讨论它们在肿瘤发生过程中和与环境交界表面的抗肿瘤免疫中的潜在作用。