a Respiratory and Sleep Diagnostics Department , Connolly Hospital , Dublin , Ireland.
b School of Biological Sciences , Dublin Institute of Technology , Dublin , Ireland.
Int J Food Sci Nutr. 2019 Mar;70(2):222-231. doi: 10.1080/09637486.2018.1492521. Epub 2018 Sep 6.
Dietary nitrate may improve exercise tolerance in some healthy and clinical populations. Existing data regarding dietary nitrate in COPD is inconsistent. We conducted a 14d double-blind, randomised, placebo-controlled, crossover trial of daily nitrate-rich beetroot juice (BRJ; 12.9 mmol) versus nitrate-depleted BRJ (PL; 0.5 mmol). At baseline and after each condition, we assessed functional capacity (incremental shuttle walk test; ISWT), ambulatory blood pressure, pulmonary function, quality of life as well as exhaled nitric oxide (eNO), and plasma nitrate/nitrite (NOx). Eight subjects with COPD completed the trial. BRJ supplementation was associated with significantly increased NOx (p < .05) and a 14.6% increase in ISWT distance (+56 m, p = .00004) as well as a trend towards increased eNO compared to PL. There was no other differences. Dietary nitrate appears to have ergogenic effect in subjects with mild-moderate COPD. This effect does not appear to be related to altering blood pressure or pulmonary function.
饮食硝酸盐可能会提高某些健康和临床人群的运动耐量。目前关于 COPD 患者饮食硝酸盐的数据并不一致。我们进行了一项为期 14 天的双盲、随机、安慰剂对照、交叉试验，比较了富含硝酸盐的甜菜根汁（BRJ；12.9mmol）与硝酸盐耗尽的 BRJ（PL；0.5mmol）。在基线和每个条件后，我们评估了功能能力（递增穿梭步行试验；ISWT）、动态血压、肺功能、生活质量以及呼气一氧化氮（eNO）和血浆硝酸盐/亚硝酸盐（NOx）。8 名 COPD 患者完成了试验。BRJ 补充与 NOx 显著增加（p<0.05）和 ISWT 距离增加 14.6%（+56m，p=0.00004）以及与 PL 相比 eNO 呈增加趋势相关。没有其他差异。饮食硝酸盐似乎对轻度至中度 COPD 患者具有增强运动能力的作用。这种作用似乎与改变血压或肺功能无关。
