Osadchuk L V, Kleschev M A, Baklanov A V, Bazhan N M
Ross Fiziol Zh Im I M Sechenova. 2016 Mar;102(3):340-50.
Parameters of spermatogenesis, androgen status and lipid metabolism (amount of abdominal fat, cholesterol and triglycerides plasma levels) in male mice with the mutation yellow at the locus agouti (Ay mice), which results in obesity after puberty were studied. Their lean littermate's mice of standard C57BL/6J strain genotype (a/a mice) were used as a control. At the age of 15 and 30 weeks the body weight, triglyceride levels, and at the age of 30 weeks - abdominal fat mass in Ay males were higher than that of a/a males. These data confirm the development of obesity and disturbance of lipid metabolism in Ay males. There were no changes in the number of sperm in the caudal epididymis, the proportion of mobile and morphologically abnormal sperm, the concentration of testosterone and its content in the testes in Ay mice at the reproductively active period (age 15 and 30 weeks). It is assumed that the ectopic expression of agouti protein in Ay males may be involved in the protection of the testicular function from the negative impact of obesity.
对携带刺鼠位点黄色突变的雄性小鼠（Ay小鼠）的精子发生参数、雄激素状态和脂质代谢（腹部脂肪量、胆固醇和甘油三酯血浆水平）进行了研究，该突变导致青春期后肥胖。它们的标准C57BL/6J品系基因型的瘦同窝小鼠（a/a小鼠）用作对照。15周和30周龄时，Ay雄性小鼠的体重、甘油三酯水平以及30周龄时的腹部脂肪量均高于a/a雄性小鼠。这些数据证实了Ay雄性小鼠肥胖的发展和脂质代谢紊乱。在生殖活跃期（15周和30周龄），Ay小鼠附睾尾部精子数量、活动精子和形态异常精子的比例、睾酮浓度及其在睾丸中的含量均无变化。推测Ay雄性小鼠中刺鼠蛋白的异位表达可能参与保护睾丸功能免受肥胖的负面影响。
