经肠胃外和口服选定二硫代氨基甲酸盐对小鼠体内镉负荷及器官分布的比较效应

Comparative effects of parenteral and oral administration of selected dithiocarbamates on body burdens and organ distribution of cadmium in mice.

作者信息

Gale G R, Atkins L M, Smith A B, Jones M M

出版信息

Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):129-32.

Abstract

Diethyldithiocarbamate (DDTC), N-methyl-N-dithiocarboxyglucamine (MDCG), and 4-carboxamidopiperidine-N-dithiocarboxylate (CAP-N-DTC) were compared at equimolar doses administered by the ip and po routes for effectiveness in mobilizing metallothionein (MT)-bound cadmium (Cd) using 109Cd in mice. DDTC was highly effective by both routes in lowering hepatic, renal, and splenic Cd levels, but enhanced redistribution of Cd to testes and brain. While MDCG and CAP-N-DTC were much less active by the oral route, each effected a significant reduction of renal Cd levels, and MDCG reduced the testicular Cd burden. Neither analog lowered hepatic Cd levels impressively when given po.

摘要

通过腹腔注射（ip）和口服（po）途径，以等摩尔剂量给予小鼠二乙基二硫代氨基甲酸盐（DDTC）、N-甲基-N-二硫代羧基葡糖胺（MDCG）和4-羧酰胺基哌啶-N-二硫代羧酸盐（CAP-N-DTC），比较它们在动员金属硫蛋白（MT）结合的镉（Cd）方面的有效性，使用的是小鼠体内的¹⁰⁹Cd。DDTC通过两种途径都能高效降低肝脏、肾脏和脾脏中的镉水平，但会增强镉向睾丸和大脑的重新分布。虽然MDCG和CAP-N-DTC经口服途径的活性要低得多，但它们各自都能显著降低肾脏中的镉水平，且MDCG减轻了睾丸中的镉负荷。口服给药时，这两种类似物都没有显著降低肝脏中的镉水平。