Cikrt M, Lepsi P, Horáková L, Bláha K, Bittnerová D, Jones M M
J Toxicol Environ Health. 1986;17(4):419-27. doi: 10.1080/15287398609530836.
One month after termination of a 3-mo exposure of rats to cadmium (Cd in drinking water at a concentration of 50 mg/l), the effects of dithiocarbamate analogs on the excretion and distribution of the cadmium were determined. Sodium salts of three dithiocarbamates [sodium bis(hydroxyethyl) dithiocarbamate, DEDTC; sodium N-methyl-D-glucamine dithiocarbamate, MGDTC; and sodium 4-carboxamidopiperidine dithiocarbamate, INADTC] were given to rats ip 2 times at 2.46 mmol/kg. In the following administration of the first injection of DEDTC, cadmium excretion via the urine amounted to 15.8 micrograms and via bile amounted to 124.4 micrograms Cd. Following administration of MGDTC, the urinary and biliary excretions of cadmium were 14.5 and 47 micrograms, respectively, while in the case of INADTC the corresponding values were 23.6 and 7.9 micrograms cadmium. In control animals the urinary and biliary excretion per 12 h reached 0.09 and 0.12 micrograms Cd. Gel permeation chromatography (GPC) analysis of bile revealed differences in the distribution of Cd in the elution fractions after the first injections of the individual dithiocarbamates. For all three dithiocarbamates, significant decreases of the concentrations of cadmium in the liver and kidney were found. DEDTC (but neither of the other compounds) increased the concentration of cadmium in the brain from control levels of 49 +/- 5 ppb to 105 +/- 16 ppb.
在大鼠接触镉（饮用水中镉浓度为50毫克/升）3个月后停止接触，1个月后测定二硫代氨基甲酸盐类似物对镉排泄和分布的影响。三种二硫代氨基甲酸钠盐[双（羟乙基）二硫代氨基甲酸钠，DEDTC；N-甲基-D-葡糖胺二硫代氨基甲酸钠，MGDTC；4-羧酰胺基哌啶二硫代氨基甲酸钠，INADTC]以2.46毫摩尔/千克的剂量腹腔注射给大鼠2次。在首次注射DEDTC后的后续给药中，经尿液排泄的镉量为15.8微克，经胆汁排泄的镉量为124.4微克。给予MGDTC后，镉的尿排泄量和胆汁排泄量分别为14.5微克和47微克，而对于INADTC，相应的值分别为23.6微克和7.9微克镉。在对照动物中，每12小时的尿排泄量和胆汁排泄量分别达到0.09微克和0.12微克镉。对胆汁进行凝胶渗透色谱（GPC）分析发现，在首次注射各二硫代氨基甲酸盐后，洗脱级分中镉的分布存在差异。对于所有三种二硫代氨基甲酸盐，均发现肝脏和肾脏中镉的浓度显著降低。DEDTC（但其他化合物均未）使大脑中镉的浓度从对照水平的49±5 ppb增加到105±16 ppb。
