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兰地洛尔：药理学及其在紧急情况下控制房颤心率方面的应用。

Landiolol: pharmacology and its use for rate control in atrial fibrillation in an emergency setting.

作者信息

Domanovits Hans, Wolzt Michael, Stix Günter

机构信息

Department of Emergency Medicine, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria.

Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria.

出版信息

Eur Heart J Suppl. 2018 Jan;20(Suppl A):A1-A3. doi: 10.1093/eurheartj/sux037. Epub 2018 Jan 8.

DOI:10.1093/eurheartj/sux037
PMID:30188959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5909771/
Abstract

This article provides new insight on landiolol, an ultra-short acting injectable betablocker, recently approved in Europe, with regard to its pharmacokinetic and pharmacodynamic profile, along with its first experience in Caucasian healthy volunteers and patients with atrial fibrillation. Landiolol as iv formulation exhibited in an emergency setting rapid rate reduction in patients with tachycardic atrial fibrillation without pronounced blood pressure drop both in caucasian and asian populations in similar manner.

摘要

本文提供了关于兰地洛尔（一种超短效注射用β受体阻滞剂，最近在欧洲获得批准）的新见解，涉及其药代动力学和药效学特征，以及其在白种健康志愿者和房颤患者中的首次应用经验。静脉注射用兰地洛尔在紧急情况下能使快速性房颤患者的心率迅速降低，在白种人和亚洲人群中均不会导致明显的血压下降，且表现相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aff7/5909771/8450e595e5cc/sux037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aff7/5909771/8450e595e5cc/sux037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aff7/5909771/8450e595e5cc/sux037f1.jpg

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本文引用的文献

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Landiolol for managing atrial fibrillation in post-cardiac surgery.兰地洛尔用于心脏手术后房颤的管理。
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2
Landiolol for managing atrial fibrillation in intensive care.兰地洛尔用于重症监护中房颤的管理。
Eur Heart J Suppl. 2018 Jan;20(Suppl A):A15-A18. doi: 10.1093/eurheartj/sux039. Epub 2018 Jan 8.
3
Landiolol for managing post-operative atrial fibrillation.兰地洛尔用于治疗术后房颤。
兰地洛尔用于心房快速性心律失常和急性失代偿性心力衰竭患者快速控制心率的疗效与安全性。
Eur Heart J Suppl. 2022 Jun 13;24(Suppl D):D11-D21. doi: 10.1093/eurheartjsupp/suac023. eCollection 2022 Jun.
4
Acute rate control in atrial fibrillation: an urgent need for the clinician.心房颤动的急性心率控制：临床医生的迫切需求。
Eur Heart J Suppl. 2022 Jun 13;24(Suppl D):D3-D10. doi: 10.1093/eurheartjsupp/suac022. eCollection 2022 Jun.
5
Expert consensus on acute management of ventricular arrhythmias - VT network Austria.奥地利室性心律失常（VT）网络急性处理专家共识
Int J Cardiol Heart Vasc. 2021 Apr 3;34:100760. doi: 10.1016/j.ijcha.2021.100760. eCollection 2021 Jun.
6
Effects of Intravenous Landiolol on Heart Rate and Outcomes in Patients with Atrial Tachyarrhythmias and Acute Decompensated Heart Failure: A Single-Center Experience.静脉注射兰地洛尔对房性快速心律失常和急性失代偿性心力衰竭患者心率及预后的影响：单中心经验
Drugs Real World Outcomes. 2019 Mar;6(1):19-26. doi: 10.1007/s40801-019-0149-1.
7
Landiolol for managing atrial fibrillation in post-cardiac surgery.兰地洛尔用于心脏手术后房颤的管理。
Eur Heart J Suppl. 2018 Jan;20(Suppl A):A4-A9. doi: 10.1093/eurheartj/sux038. Epub 2018 Jan 8.
Eur Heart J Suppl. 2018 Jan;20(Suppl A):A10-A14. doi: 10.1093/eurheartj/sux036. Epub 2018 Jan 8.
4
Landiolol for rate control management of atrial fibrillation in patients with cardiac dysfunction.兰地洛尔用于心功能不全患者房颤的心率控制管理。
Eur Heart J Suppl. 2018 Jan;20(Suppl A):A19-A24. doi: 10.1093/eurheartj/sux035. Epub 2018 Jan 8.
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Perioperative landiolol administration reduces atrial fibrillation after cardiac surgery: A meta-analysis of randomized controlled trials.围手术期使用兰地洛尔可降低心脏手术后房颤的发生率：一项随机对照试验的荟萃分析。
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Drugs. 2013 Jun;73(9):959-77. doi: 10.1007/s40265-013-0077-4.