Smith T J, Kremer M J, Luo M, Vriend G, Arnold E, Kamer G, Rossmann M G, McKinlay M A, Diana G D, Otto M J
Science. 1986 Sep 19;233(4770):1286-93. doi: 10.1126/science.3018924.
WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 beta-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.
WIN 51711和WIN 52084是结构相关的抗病毒化合物，可抑制鼻病毒（普通感冒病毒）及相关微小核糖核酸病毒的复制。它们可阻止pH介导的病毒RNA脱壳。这些化合物由一个插入VP1β桶疏水内部的3-甲基异恶唑基团、一条连接的七元脂肪链以及一个覆盖“峡谷”底部离子通道入口的4-恶唑啉基苯氧基（OP）组成。病毒解体可能通过阻止VP1疏水口袋的塌陷或通过阻断离子流入病毒内部而受到抑制。
