Mazzotta Elisabetta, Tavano Lorena, Muzzalupo Rita
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Savinio, Ed. Polifunzionale, 87036 Arcavacata di Rende, Italy.
Pharmaceutics. 2018 Sep 5;10(3):150. doi: 10.3390/pharmaceutics10030150.
Thermo-sensitive vesicles are a promising tool for triggering the release of drugs to solid tumours when used in combination with mild hyperthermia. Responsivity to temperature makes them intelligent nanodevices able to provide a site-specific chemotherapy. Following a brief introduction concerning hyperthermia and its advantageous combination with vesicular systems, recent investigations on thermo-sensitive vesicles useful for controlled drug delivery in cancer treatment are reported in this review. In particular, the influence of bilayer composition on the in vitro and in vivo behaviour of thermo-sensitive formulations currently under investigation have been extensively explored.
热敏囊泡与轻度热疗联合使用时，是一种很有前景的将药物释放到实体肿瘤的工具。对温度的响应性使其成为能够提供位点特异性化疗的智能纳米装置。在简要介绍了热疗及其与囊泡系统的优势组合之后，本文综述了近期关于可用于癌症治疗中药物控释的热敏囊泡的研究。特别是，目前正在研究的双层组成对热敏制剂体外和体内行为的影响已得到广泛探索。
