比较即时检测（POC）和高效液相色谱法（HPLC）检测的糖化血红蛋白（HbA1C）。

Comparing HbA1C by POC and HPLC.

作者信息

Agrawal Sungeeta, Reinert Steven E, Baird Grayson L, Quintos Jose Bernardo

机构信息

Division of Pediatric Endocrinology, Tufts Medical Center/ Tufts University School of Medicine, Boston, MA.

Lifespan Information Services, Rhode Island Hospital, Providence, RI.

出版信息

R I Med J (2013). 2018 Sep 4;101(7):43-46.

PMID:30189704

Abstract

OBJECTIVE

Point-of-care (POC) Hemoglobin A1C (HbA1C) testing is frequently used to assess glycemic control in diabetes management. Studies are lacking on the comparison of POC with high performance liquid chromatography (HPLC) when the POC HbA1C is ≥ 14%.

METHODS

Retrospective chart review of children with T1DM at Rhode Island Hospital from 2007-2013. Primary objective was to delineate the range of HPLC HbA1C values when the POC is ≥ 14% and characterize these patients.

PRIMARY RESULTS

There were 72 patients, 5-21 years old, with corresponding POC and HPLC tests. Nineteen children, mean age 16.1 years, had a POC HbA1C ≥ 14%. Their mean HPLC value was 14.1% (95% CI [13.4, 14.8]), with range 11.1-16.3 and standard deviation 1.4%.

CONCLUSION

There is wide variation when POC HbA1C values are ≥ 14%. We suggest routine central HbA1C testing when the POC is ≥ 14% for proper counseling and follow-up of glycemic control. Tracking relative changes in HbA1C at subsequent clinic visits is important as it allows clinicians to gauge whether or not interventions are effective. Additionally, knowledge that their HbA1C is trending down may provide positive reinforcement to adolescents.

摘要

目的

即时检验（POC）糖化血红蛋白（HbA1C）检测常用于评估糖尿病管理中的血糖控制情况。当POC HbA1C≥14%时，缺乏关于POC检测与高效液相色谱法（HPLC）比较的研究。

方法

对罗德岛医院2007年至2013年的1型糖尿病患儿进行回顾性病历审查。主要目的是确定当POC≥14%时HPLC HbA1C值的范围，并对这些患者进行特征描述。

主要结果

共有72例年龄在5至21岁之间的患者进行了相应的POC和HPLC检测。19名平均年龄为16.1岁的儿童POC HbA1C≥14%。他们的平均HPLC值为14.1%（95%置信区间[13.4, 14.8]），范围为11.1 - 16.3，标准差为1.4%。

结论

当POC HbA1C值≥14%时存在很大差异。我们建议当POC≥14%时进行常规的中心HbA1C检测，以便对血糖控制进行适当的咨询和随访。在随后的门诊就诊时追踪HbA1C的相对变化很重要，因为这使临床医生能够判断干预措施是否有效。此外，了解他们的HbA1C呈下降趋势可能会给青少年带来积极的强化作用。