Giza Stephanie A, Olmstead Craig, McCooeye Daniel A, Miller Michael R, Penava Deborah A, Eastabrook Genevieve D, McKenzie Charles A, de Vrijer Barbra
Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
J Matern Fetal Neonatal Med. 2020 Mar;33(5):831-837. doi: 10.1080/14767058.2018.1506438. Epub 2018 Sep 6.
Analysis of fetal adipose tissue volumes may provide useful insight towards assessment of overall fetal health, especially in cases with abnormal fetal growth. Here, we assess whether fetal adipose tissue volume can be reliably measured using 3D water-fat MRI, using a quantitative assessment of the lipid content of tissues. Seventeen women with singleton pregnancies underwent a fetal MRI and water-only and fat-only images were acquired (modified 2-point Dixon technique). Water and fat images were used to generate a fat signal fraction (fat/(water + fat)) from which subcutaneous adipose tissue was segmented along the fetal trunk. Inter-rater (three readers) and intrarater reliability was assessed using intraclass-correlation coefficients (ICC) for 10 image sets. Relationships between adipose tissue measurements and gestational age and estimated fetal weight percentiles were examined. The ICC of the inter-rater reliability was 0.936 ( < .001), and the ICC of the intrarater reliability was 0.992 ( < .001). Strong positive correlations were found between adipose tissue measurements (lipid volume, lipid volume/total fetal volume, mean fat signal fraction) and gestational age. 3D water-fat MRI can reliably measure volume and quantify lipid content of fetal subcutaneous adipose tissues.
分析胎儿脂肪组织体积可能为评估胎儿整体健康状况提供有用的见解，尤其是在胎儿生长异常的情况下。在此，我们使用对组织脂质含量的定量评估，来评估是否可以使用三维水脂磁共振成像（MRI）可靠地测量胎儿脂肪组织体积。17名单胎妊娠女性接受了胎儿MRI检查，并采集了纯水和纯脂肪图像（改良两点 Dixon 技术）。水和脂肪图像用于生成脂肪信号分数（脂肪/（水 + 脂肪）），并据此沿胎儿躯干分割皮下脂肪组织。使用组内相关系数（ICC）对10组图像评估评分者间（三位读者）和评分者内的可靠性。研究了脂肪组织测量值与胎龄和估计胎儿体重百分位数之间的关系。评分者间可靠性的ICC为0.936（<0.001），评分者内可靠性的ICC为0.992（<0.001）。在脂肪组织测量值（脂质体积、脂质体积/胎儿总体积、平均脂肪信号分数）与胎龄之间发现了强正相关。三维水脂MRI可以可靠地测量胎儿皮下脂肪组织的体积并量化脂质含量。
