Key Lab of Public Health Safety of Ministry of Education and Key Lab of Health Technology Assessment of Ministry of Health, School of Public Health, Fudan University, No. 130 Dongan RD, Xuhui District, Shanghai, Zip code: 200032, China.
School of Public Health, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Rd, Pudong New Area, Shanghai, Zip code: 201203, China.
J Transl Med. 2018 Sep 6;16(1):250. doi: 10.1186/s12967-018-1618-0.
Even though multi-focused psychosocial residence rehabilitation intervention (MPRRI) programs are widely implemented by the Shanghai Cancer Rehabilitation Club, these programs have not been rigorously evaluated. In this study, we evaluated the effects of a 21-day MPRRI program, on the quality of life (QoL) among cancer survivors.
A total of 388 cancer patients were enrolled to either receive the 21-day MPRRI (n = 129) intervention or a waiting-list comparison (WLC) intervention (n = 259). The intervention group was offered community-based 21-day MPRRI program, combining supportive-expressive group, cognitive-behavioral therapy, and Guolin Qigong. QoL was measured using the European Organization for Research and Treatment Quality of Life Version 3 Questionnaire. Multivariable linear models were used to compare changes in QoL values between the two groups.
After adjustment for the QoL score and other covariates at baseline, there was no significant difference in global health status (mean = 3.8, 95% CI - 1.3-9.0, P = 0.14) between the two groups after 6 months intervention. While compared with the WLC group, the intervention group showed significant improvements in the QoL score (all P < 0.05); however, there were no clinically relevant changes in subscales including emotional functioning (ES = 0.58), cognitive functioning (ES = 0.53), pain (ES = 0.52), physical functioning (ES = 0.36), and insomnia (ES = 0.30).
These preliminary results suggest the MPRRI program is both feasible and acceptable intervention for cancer survivors in community settings and is effective in significant improving QoL above.
尽管上海癌症康复俱乐部广泛实施了多焦点心理社会居住康复干预(MPRRI)计划,但这些计划尚未经过严格评估。在这项研究中,我们评估了为期 21 天的 MPRRI 计划对癌症幸存者生活质量(QoL)的影响。
共招募了 388 名癌症患者,分别接受 21 天的 MPRRI(n=129)干预或等待名单对照(WLC)干预(n=259)。干预组接受基于社区的 21 天 MPRRI 计划,结合支持性表达小组、认知行为疗法和郭林气功。使用欧洲癌症研究与治疗组织生活质量问卷 3 版测量 QoL。使用多变量线性模型比较两组之间 QoL 值的变化。
调整基线时的 QoL 评分和其他协变量后,6 个月干预后两组的总体健康状况评分(均值=3.8,95%CI-1.3-9.0,P=0.14)没有显著差异。与 WLC 组相比,干预组的 QoL 评分显著提高(均 P<0.05);然而,情绪功能(ES=0.58)、认知功能(ES=0.53)、疼痛(ES=0.52)、身体功能(ES=0.36)和失眠(ES=0.30)等子量表没有明显的临床相关变化。
这些初步结果表明,MPRRI 计划在社区环境中对癌症幸存者既可行又可接受,并且在显著提高 QoL 方面是有效的。