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没食子酸表没食子儿茶素酯抑制人肝嵌合体小鼠乙型肝炎病毒感染。

Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice.

机构信息

Department of Chemistry, Chinese Culture University, Taipei, 11114, Taiwan.

Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.

出版信息

BMC Complement Altern Med. 2018 Sep 6;18(1):248. doi: 10.1186/s12906-018-2316-4.

DOI:10.1186/s12906-018-2316-4
PMID:30189898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6127945/
Abstract

BACKGROUND

Persistent hepatitis B virus (HBV) infection causes liver cirrhosis and hepatocellular carcinoma and constitutes a major worldwide health problem. Currently, anti-HBV drugs are limited to peginterferon and nucleos(t)ide analogs, which are costly and have considerable side effects; the development of novel, effective anti-HBV agents is crucial.

METHODS

Catechins are a major group of compounds found in green tea extract and epigallocatechin gallate (EGCG) has been shown to have antiviral properties, including inhibition of cellular entry by HBV. FRG (Fah/ Rag2/ IL-2Rγ) mice were used in this study to generate chimeras carrying human primary hepatocytes, to facilitate investigation of the inhibitory effect of EGCG on HBV infection.

RESULTS

Here, we show the inhibitory effect of EGCG on HBV infection and replication in HuS-E/2 cells. The inhibitory effect of EGCG on HBV infection in vivo was confirmed by monitoring HBV DNA and HBsAg in serum and immunostaining the liver tissues of the human liver chimeric mice.

CONCLUSIONS

The effects of EGCG suggest a robust strategy for the treatment of HBV infection and EGCG may have therapeutic potential for the treatment of HBV-associated liver diseases.

摘要

背景

持续性乙型肝炎病毒（HBV）感染可导致肝硬化和肝细胞癌，是一个全球性的重大健康问题。目前，抗 HBV 药物仅限于聚乙二醇干扰素和核苷（酸）类似物，这些药物昂贵且有相当大的副作用；开发新型、有效的抗 HBV 药物至关重要。

方法

儿茶素是绿茶提取物中的主要化合物群，表没食子儿茶素没食子酸酯（EGCG）已被证明具有抗病毒特性，包括抑制 HBV 的细胞进入。本研究使用 Fah/Rag2/IL-2Rγ（FRG）小鼠来生成携带人原代肝细胞的嵌合体，以方便研究 EGCG 对 HBV 感染的抑制作用。

结果

我们展示了 EGCG 对 HuS-E/2 细胞中 HBV 感染和复制的抑制作用。通过监测血清中 HBV DNA 和 HBsAg 以及对人肝嵌合小鼠的肝组织进行免疫染色，证实了 EGCG 对 HBV 感染的体内抑制作用。

结论

EGCG 的作用表明了一种治疗 HBV 感染的有效策略，EGCG 可能具有治疗 HBV 相关肝病的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/4c75300931fb/12906_2018_2316_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/cb6d102d50ec/12906_2018_2316_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/09abcd1fcf12/12906_2018_2316_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/566bb5313871/12906_2018_2316_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/d92b25e1a1bd/12906_2018_2316_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/4c75300931fb/12906_2018_2316_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/cb6d102d50ec/12906_2018_2316_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/09abcd1fcf12/12906_2018_2316_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/566bb5313871/12906_2018_2316_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/d92b25e1a1bd/12906_2018_2316_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6222/6127945/4c75300931fb/12906_2018_2316_Fig5_HTML.jpg

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